HVIDB-PPI detail

Q16763 (UBE2S)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: UBE2S_HUMAN

UniProtID: Q16763

Gene name(s): UBE2S;E2EPF;OK/SW-cl.73

Protein name: Ubiquitin-conjugating enzyme E2 S

Gene ID: 27338

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q16763-P27958	PHISTO	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.075).

Combined Score: 0.041

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
897	UBE2S-RUSC1-ELMO3	3	0.33 (1/3)	NA	hu.MAP	View
925	RNF40-UBE2S	2	0.50 (1/2)	NA	hu.MAP	View
1793	USP6NL-UBE2S-RNF40-RUSC1-ELMO3	5	0.20 (1/5)	NA	hu.MAP	View
3602	UBE2S-RUSC1	2	0.50 (1/2)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE84188	mock_infected_1d	EBOV_infected_1d	up	1.97	1.96e-05	RNA-Seq data
GSE30589	MA-104_Mock_infected_0h	MA-104_SARS-Cov_DeltaE_65h	down	-1.85	2.92e-06	Microarray data
GSE30589	MA-104_Mock_infected_0h	MA-104_SARS-Cov_WT_65h	down	-2.41	8.82e-07	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-2.65	2.30e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-3.16	5.58e-07	Microarray data
GSE30589	Vero_E6_Mock_infected_7hpi	Vero_E6_SARS-Cov_DeltaE_7hpi	down	-2.02	1.63e-05	Microarray data
GSE30589	Vero_E6_Mock_infected_7hpi	Vero_E6_SARS-Cov_WT_7hpi	down	-2.36	2.98e-03	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	1.79	2.79e-03	Microarray data
GSE30723	AMs_control_4h	AMs_PR8_4h	up	1.93	1.19e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-1.81	3.21e-04	Microarray data
GSE49628	Bcells_Quiescent	Bcells_Activation	up	2.81	2.55e-04	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	up	3.22	2.93e-04	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	3.28	6.08e-03	Microarray data
GSE92496	control_vector	HPV16_E6-E7_vector	up	1.86	1.71e-07	RNA-Seq data
GSE93385	K048_mock_infected	K048_ZIKV_infected	down	-1.60	5.87e-12	RNA-Seq data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-2.29	5.58e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-1.87	1.18e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	down	-1.83	1.28e-03	Microarray data
GSE99298	mock_infected_0h	hRSV_WT_infected_96h	up	2.18	5.02e-08	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-1.81	2.31e-03	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	1.86	2.51e-09	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-2.21	5.17e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-1.82	7.67e-03	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	1.70	6.77e-15	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	2.08	1.89e-17	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	2.82	1.34e-40	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	2.05	1.79e-09	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	2.17	1.22e-23	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_72h	down	-2.05	3.90e-02	Microarray data
GSE93861	healthy_blood_control	Ebola_infection	up	2.31	6.14e-20	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000108106
Gene description:	Ubiquitin conjugating enzyme E2 S
Chromosome:	19
Position	55399745-55407777
Protein class:	Enzymes, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm, Plasma membrane