Q16644 (MAPKAPK3)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: MAPK3_HUMAN

UniProtID: Q16644

Gene name(s): MAPKAPK3

Protein name: MAP kinase-activated protein kinase 3

Gene ID: 7867

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q16644-P27958PHISTO23487458anti bait coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.073).
Combined Score: 0.039


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
4260MAPKAPK3-MAPK1120.50 (1/2)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE32155CRL-5800_unifectedCRL-5807_infectedup2.131.09e-05Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infectedup1.945.68e-05Microarray data
GSE32155HTB-3_unifectedHTB-174_infectedup1.701.72e-04Microarray data
GSE32155HTB-4_unifectedHTB-174_infectedup2.744.01e-05Microarray data
GSE50938polysomal_RNA_mock-infected_NHDFspolysomal_RNA_HCMV-infected_HNDFs_48h_post-infectionup1.745.06e-03Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hdown-2.913.06e-04Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-3.428.73e-05Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-1.721.81e-02Microarray data
GSE65574MCL001_mock_7hMCL001_RFP-MERS_7hdown-1.917.69e-03Microarray data
GSE97672-GPL16791MDM-418_H3N2_MOI0_18hMDM-418_H3N2_MOI2_18hdown-1.611.98e-24RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-2.061.60e-24RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-1.714.82e-20RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 26.8 Liver: 7.5 Gallbladder: 19.1 Duodenum: 30.6 Rectum: 22.0 Tonsil: 22.1 Stomach: 19.2 Salivary glanda: 9.0 Adipose tissue: 18.1 Lung: 41.4 Lymph node: 24.4 Pancreas: 7.2 Kidney: 32.3 Colon: 19.3 Appendix: 40.5 Smooth musle: 23.1 Breast: 19.5 Parathyroid gland: 51.6 Esophagus: 43.3 Heart muscle: 117.6 Spleen: 31.8 Skeletal muscle: 69.0 Bone marrow: 67.5 Skin: 55.5 Urinary bladder: 22.2 Cervix, uterine: 16.5 Endometrium: 16.3 Ovary: 16.4 Fallopian tube: 24.6 Seminal vesicle: 17.8 Prostate: 26.2 Epididymis: 12.5 Testis: 15.0 Placenta: 20.1 Thyroid gland: 68.9 Cerebral cortex: 14.7 Adrenal gland: 33.4
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000114738
Gene description:Mitogen-activated protein kinase-activated protein kinase 3
Chromosome:3
Position50611520-50649297
Protein class:Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm