HVIDB-PPI detail

Q16531 (DDB1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: DDB1_HUMAN

UniProtID: Q16531

Gene name(s): DDB1;XAP1

Protein name: DNA damage-binding protein 1

Gene ID: 1642

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q16531-P27958	biogrid,HPIDB	23137809	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.245).

Combined Score: 0.414

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1162	Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1)	5	0.20 (1/5)	16678110	CORUM	View
1211	Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1)	6	0.17 (1/6)	17392787	CORUM	View
1214	Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)	5	0.20 (1/5)	14739464	CORUM	View
1335	SNW1 complex	18	0.17 (3/18)	12840015	CORUM	View
2172	Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1)	4	0.25 (1/4)	15448697	CORUM	View
2722	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)	3	0.33 (1/3)	15448697	CORUM	View
391	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)	3	0.33 (1/3)	16964240	CORUM	View
6290	Ubiquitin E3 ligase (DDB1, DYRK2, EDD, VPRBP)	4	0.25 (1/4)	19287380	CORUM	View
6291	Ubiquitin E3 ligase (DDIT4, DDB1, BTRC, CUL4A)	4	0.25 (1/4)	19557001	CORUM	View
6482	CUL4B-DDB1-DTL-CSN complex	5	0.20 (1/5)	16861906	CORUM	View
6486	CUL4A-DDB1-DTL complex	3	0.33 (1/3)	16861906	CORUM	View
6487	CUL4B-DDB1-TLE2 complex	3	0.33 (1/3)	17041588	CORUM	View
6488	CUL4A-DDB1-EED complex	3	0.33 (1/3)	17041588	CORUM	View
6489	CUL4A-DDB1-WDR5 complex	3	0.67 (2/3)	17041588	CORUM	View
6490	CUL4B-DDB1-WDR26 complex	3	0.33 (1/3)	17041588	CORUM	View
6491	CUL4A-DDB1-RBBP5 complex	3	0.33 (1/3)	17041588	CORUM	View
6492	CUL4A-DDB1-WDR5B complex	3	0.33 (1/3)	17041588	CORUM	View
6493	CUL4A-DDB1-WDR57 complex	3	0.33 (1/3)	17041588	CORUM	View
6494	CUL4A-DDB1-WDR61 complex	3	0.33 (1/3)	17041588	CORUM	View
6495	CUL4B-DDB1-GRWD1 complex	3	0.33 (1/3)	17041588	CORUM	View
6550	CUL4B-DDB1-TLE1 complex	3	0.33 (1/3)	17041588	CORUM	View
6553	CUL4B-DDB1-TLE3 complex	3	0.33 (1/3)	17041588	CORUM	View
6875	CRBN-DDB1-CUL4A-RBX1 E3 ubiquitin ligase	4	0.25 (1/4)	20223979	CORUM	View
726	DDB2 complex	12	0.08 (1/12)	12732143	CORUM	View
727	CSA complex	12	0.08 (1/12)	12732143	CORUM	View
728	CSA-POLIIa complex	13	0.08 (1/13)	12732143	CORUM	View
790	DDB complex	2	0.50 (1/2)	16223728	CORUM	View
929	CEN complex	37	0.08 (3/37)	15009096	CORUM	View
2910	DDB complex	6	0.17 (1/6)	NA	hu.MAP	View
3747	DDB complex	3	0.33 (1/3)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE68673	A549_uninfected	A549_infected	down	-1.55	4.65e-17	RNA-Seq data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-1.84	1.41e-03	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-1.84	1.28e-02	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-1.93	1.20e-03	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-1.80	7.52e-06	Microarray data
GSE40711	mock_infected_6h	IDN3006_or_cl2PA_infected_6h	down	-1.88	1.33e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	down	-2.11	2.66e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.93	2.17e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-1.59	4.43e-05	Microarray data
GSE59226	Control	Virus_infection	down	-1.87	1.49e-04	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-1.77	7.17e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-1.56	9.97e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-1.63	6.72e-04	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-1.63	6.88e-04	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_6h	HTBE_H5N1_MOI5_infected_6h	down	-1.57	7.34e-18	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-3.03	5.54e-53	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-3.65	2.25e-153	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-1.77	2.23e-35	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-1.79	3.88e-03	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-2.57	2.90e-75	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-1.98	3.97e-41	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-2.24	5.83e-51	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.78	1.16e-85	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-1.70	1.82e-31	RNA-Seq data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	down	-1.62	1.36e-03	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000167986
Gene description:	Damage specific DNA binding protein 1
Chromosome:	11
Position	61299451-61342596
Protein class:	Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm