Q15796 (SMAD2)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: SMAD2_HUMAN

UniProtID: Q15796

Gene name(s): SMAD2;MADH2;MADR2

Protein name: Mothers against decapentaplegic homolog 2

Gene ID: 4087

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q15796-P27958biogrid,HPIDB23781096affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.111).
Combined Score: 0.072


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1827PML-SMAD2/3-SARA complex40.75 (3/4)15356634CORUMView
2829RSmad complex100.30 (3/10)16751102CORUMView
2830TIF1gamma-SMAD2-SMAD3 complex30.67 (2/3)16751102CORUMView
2834SMAD4-SMAD2-SMAD3 complex30.67 (2/3)16751102CORUMView
3038SMAD2-SMAD4-FAST1 complex30.33 (1/3)9389648CORUMView
3039SMAD2-FAST1 complex20.50 (1/2)9389648CORUMView
3198SKI-SMAD2 complex20.50 (1/2)10485843CORUMView
3204SMAD2-SKI-NCOR complex30.33 (1/3)10485843CORUMView
3233SMAD2-SMAD4-FAST1-TGIF complex, TGF(beta) induced40.25 (1/4)9389648CORUMView
3234SMAD2-SMAD4-FAST1-TGIF-HDAC1 complex, TGF(beta) induced50.20 (1/5)10199400CORUMView
3729SKI-SMAD2 complex20.50 (1/2)17283070CORUMView
3739SKI-SMAD2-SMAD4 pentameric complex30.33 (1/3)17283070CORUMView
3749CREBBP-SMAD2 hexameric complex21.00 (2/2)17283070CORUMView
3753CREBBP-SMAD2-SMAD4 pentameric complex30.67 (2/3)17283070CORUMView
6513MAN1-SMAD2 complex20.50 (1/2)23779087CORUMView
6646SMAD2-SMAD4-WWTR1 complex30.33 (1/3)18568018CORUMView
2965MAN1-SMAD2 complex40.50 (2/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE32140-GPL6480mock_for_RSV_2hRSV_infectiondown-1.665.67e-06Microarray data
GSE32155CRL-5800_unifectedCRL-5807_infecteddown-2.061.87e-05Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infecteddown-2.365.22e-05Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-3.384.47e-06Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-2.041.57e-05Microarray data
GSE65123healthy_seronegative_controlHCV_infecteddown-2.503.66e-02Microarray data

Human tissue specific expression (TPM)

Small intestine: 41.3 Liver: 18.4 Gallbladder: 62.4 Duodenum: 37.0 Rectum: 53.7 Tonsil: 50.4 Stomach: 42.7 Salivary glanda: 15.4 Adipose tissue: 54.7 Lung: 69.5 Lymph node: 51.3 Pancreas: 8.5 Kidney: 46.4 Colon: 47.2 Appendix: 51.9 Smooth musle: 70.4 Breast: 57.3 Parathyroid gland: 66.0 Esophagus: 61.0 Heart muscle: 35.3 Spleen: 65.5 Skeletal muscle: 19.8 Bone marrow: 24.2 Skin: 37.5 Urinary bladder: 60.6 Cervix, uterine: 66.4 Endometrium: 64.5 Ovary: 64.7 Fallopian tube: 75.9 Seminal vesicle: 62.9 Prostate: 59.4 Epididymis: 49.9 Testis: 95.3 Placenta: 61.0 Thyroid gland: 126.7 Cerebral cortex: 54.3 Adrenal gland: 69.0
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000175387
Gene description:SMAD family member 2
Chromosome:18
Position47808957-47931146
Protein class:Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Evidence:Evidence at protein level
Subcellular location:Nucleus, Nucleoli, Cytosol