Q14318 (FKBP8)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: FKBP8_HUMAN

UniProtID: Q14318

Gene name(s): FKBP8;FKBP38

Protein name: Peptidyl-prolyl cis-trans isomerase FKBP8

Gene ID: 23770

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q14318-P27958PHISTO,biogrid,HPIDB,VirusMentha22810585affinity chromatography technology,tandem affinity purification

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: yes (score 0.039). Show
Machine learning evidence: yes (score 0.149).
Combined Score: 0.968


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
4158HSP90-FKBP38-CAM-Ca(2+) complex30.67 (2/3)17379601CORUMView
5526CALM1-FKBP38-BCL2 complex30.33 (1/3)15990872CORUMView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hdown-1.712.32e-02Microarray data
GSE73072H1N1_DEE4_0hH1N1_DEE4_101hdown-2.041.42e-14Microarray data
GSE73072H1N1_DEE4_0hH1N1_DEE4_125hdown-2.156.26e-14Microarray data
GSE73072H1N1_DEE4_0hH1N1_DEE4_12hdown-1.761.23e-08Microarray data
GSE73072H1N1_DEE4_0hH1N1_DEE4_132hdown-2.211.27e-15Microarray data
GSE73072H1N1_DEE4_0hH1N1_DEE4_29hdown-1.683.24e-08Microarray data
GSE73072H1N1_DEE4_0hH1N1_DEE4_36hdown-1.731.01e-08Microarray data
GSE73072H1N1_DEE4_0hH1N1_DEE4_77hdown-1.509.01e-07Microarray data
GSE73072H1N1_DEE4_0hH1N1_DEE4_84hdown-1.883.67e-12Microarray data
GSE73072H1N1_DEE4_0hH1N1_DEE4_94hdown-1.681.73e-11Microarray data

Human tissue specific expression (TPM)

Small intestine: 96.4 Liver: 44.4 Gallbladder: 131.6 Duodenum: 84.8 Rectum: 36.5 Tonsil: 48.3 Stomach: 82.4 Salivary glanda: 88.8 Adipose tissue: 139.4 Lung: 138.6 Lymph node: 106.4 Pancreas: 34.5 Kidney: 71.9 Colon: 74.7 Appendix: 105.5 Smooth musle: 91.5 Breast: 80.0 Parathyroid gland: 117.6 Esophagus: 141.7 Heart muscle: 78.6 Spleen: 144.5 Skeletal muscle: 59.9 Bone marrow: 163.2 Skin: 113.1 Urinary bladder: 96.2 Cervix, uterine: 132.4 Endometrium: 135.9 Ovary: 175.4 Fallopian tube: 165.1 Seminal vesicle: 160.7 Prostate: 151.3 Epididymis: 73.7 Testis: 257.7 Placenta: 129.4 Thyroid gland: 112.3 Cerebral cortex: 354.7 Adrenal gland: 128.6
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000105701
Gene description:FK506 binding protein 8
Chromosome:19
Position18531751-18544077
Protein class:Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Evidence:Evidence at protein level
Subcellular location:Endoplasmic reticulum, Mitochondria, Cytosol