Q14247 (CTTN)
Homo sapiensP27958-PRO_0000037566 (NA)
Hepatitis C virus genotype 1a (isolate H) (HCV)Human protein: SRC8_HUMAN
UniProtID: Q14247
Gene name(s): CTTN;EMS1
Protein name: Src substrate cortactin
Gene ID: 2017
HDF/HRF: NA
Virus protein: Core protein p21(POLG_HCVH) (HCV-H)
UniProtID: P27958-PRO_0000037566
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| Q14247-P27958-PRO_0000037566 | HPIDB | 23487458 | protein array |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 1130 | Hip1R-cortactin complex | 2 | 0.50 (1/2) | 17318189 | CORUM | View |
| 5318 | DDEF1-CTTN-PXN complex | 3 | 0.33 (1/3) | 15719014 | CORUM | View |
| 6076 | c-Abl-cortactin-nmMLCK complex | 3 | 0.33 (1/3) | 20861316 | CORUM | View |
| 6282 | G alpha-13-Hax-1-cortactin-Rac complex | 4 | 0.25 (1/4) | 15339924 | CORUM | View |
| 6916 | CTTN-FER-PTK2 complex | 3 | 0.33 (1/3) | 19339212 | CORUM | View |
| 233 | actin bindin | 29 | 0.03 (1/29) | NA | hu.MAP | View |
| 254 | CART complex | 30 | 0.10 (3/30) | NA | hu.MAP | View |
| 837 | GR-hnRNP U complex | 4 | 0.25 (1/4) | NA | hu.MAP | View |
| 1965 | GR-hnRNP U complex | 4 | 0.25 (1/4) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE45042 | ELC001_mock_infected_24h | ECL001_EMC_infected_24h | down | -1.69 | 7.40e-05 | Microarray data |
| GSE49628 | Bcells_Quiescent | Bcells_EBV_transformed | up | 1.84 | 5.14e-04 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_Anhui01_pCalu3_24h | down | -1.81 | 2.03e-06 | Microarray data |
| GSE99298 | mock_infected_0h | hRSV_NS1_L132A_L133A_infected_96h | down | -2.18 | 5.37e-05 | RNA-Seq data |
| GSE97672-GPL16791 | MDM-418_H3N2_MOI0_18h | MDM-418_H3N2_MOI2_18h | down | -1.84 | 3.28e-35 | RNA-Seq data |
| GSE97672-GPL16791 | MDM-520_H5N1_MOI0_18h | MDM-520_H5N1_MOI2_18h | down | -1.81 | 1.34e-30 | RNA-Seq data |
| GSE97672-GPL18573 | MDM-513_H5N1_MOI0_18h | MDM-513_H5N1_MOI2_18h | down | -2.01 | 4.03e-36 | RNA-Seq data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000085733 |
| Gene description: | Cortactin |
| Chromosome: | 11 |
| Position | 70398404-70436584 |
| Protein class: | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Golgi apparatus, Vesicles, Plasma membrane, Cytosol |