Q14141 (SEPTIN6)

Homo sapiens

P27958-PRO_0000037577 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: SEPT6_HUMAN

UniProtID: Q14141

Gene name(s): SEPTIN6;KIAA0128;SEP2;SEPT6

Protein name: Septin-6

Gene ID: 23157

HDF/HRF: NA

Virus protein: RNA-directed RNA polymerase(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037577

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q14141-P27958-PRO_0000037577HPIDB17229681anti bait coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.103).
Combined Score: 0.064


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1716RNF40-SEPT14-ANLN-SEPT3-SEPT11-SEPT660.17 (1/6)NAhu.MAPView
2053Septin complex130.08 (1/13)NAhu.MAPView
2188Septin complex150.07 (1/15)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE32155CRL-5800_unifectedCRL-1472_infecteddown-2.494.94e-05Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infecteddown-4.776.44e-07Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infecteddown-2.904.38e-06Microarray data
GSE32155HTB-4_unifectedHTB-174_infecteddown-1.726.89e-04Microarray data
GSE45042ELC001_mock_infected_24hECL001_EMC_infected_24hdown-1.855.86e-03Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hup3.631.16e-06Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_Pan99_pCalu3_24hup2.311.52e-05Microarray data
GSE59226ControlVirus_infectiondown-2.071.53e-04Microarray data

Human tissue specific expression (TPM)

Small intestine: 19.2 Liver: 10.9 Gallbladder: 27.5 Duodenum: 14.4 Rectum: 20.4 Tonsil: 94.9 Stomach: 17.4 Salivary glanda: 7.9 Adipose tissue: 15.4 Lung: 24.3 Lymph node: 140.7 Pancreas: 0.9 Kidney: 16.2 Colon: 19.0 Appendix: 87.7 Smooth musle: 35.1 Breast: 15.5 Parathyroid gland: 13.7 Esophagus: 19.9 Heart muscle: 9.7 Spleen: 85.0 Skeletal muscle: 1.5 Bone marrow: 39.0 Skin: 6.9 Urinary bladder: 26.7 Cervix, uterine: 16.3 Endometrium: 18.4 Ovary: 14.2 Fallopian tube: 29.7 Seminal vesicle: 56.1 Prostate: 21.5 Epididymis: 20.2 Testis: 76.2 Placenta: 21.0 Thyroid gland: 10.9 Cerebral cortex: 25.4 Adrenal gland: 91.6
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000125354
Gene description:Septin 6
Chromosome:X
Position119615724-119693370
Protein class:Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Cytosol