Human protein: SKP2_HUMAN
UniProtID: Q13309
Gene name(s): SKP2;FBXL1
Protein name: S-phase kinase-associated protein 2
Gene ID: 6502
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| Q13309-P27958 | biogrid,HPIDB | 27194766 | affinity chromatography technology |
| Interolog evidence: | none/insignificant. |
| DDI evidence: | none/insignificant. |
| Machine learning evidence: | yes (score 0.113). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 1051 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, RBX1) | 4 | 0.25 (1/4) | 10230406 | CORUM | View |
| 226 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) | 3 | 0.33 (1/3) | 12609982 | CORUM | View |
| 2604 | P-TEFb-SKP2 complex | 3 | 0.33 (1/3) | 11689688 | CORUM | View |
| 2715 | Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) | 8 | 0.12 (1/8) | 11337588 | CORUM | View |
| 3015 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | 8 | 0.12 (1/8) | 17409098 | CORUM | View |
| 3036 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) | 5 | 0.20 (1/5) | 17409098 | CORUM | View |
| 5320 | CDH1-SKP2 complex | 2 | 0.50 (1/2) | 15014502 | CORUM | View |
| 615 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) | 3 | 0.33 (1/3) | 9736735 | CORUM | View |
| 781 | URI complex (Unconventional prefoldin RPB5 Interactor) | 9 | 0.22 (2/9) | 14615539 | CORUM | View |
| 80 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, RBX1) | 4 | 0.25 (1/4) | 11961546 | CORUM | View |
| 2452 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | 7 | 0.14 (1/7) | NA | hu.MAP | View |
| 2788 | Cdt1-Geminin complex | 6 | 0.17 (1/6) | NA | hu.MAP | View |
| 3285 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | 15 | 0.13 (2/15) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE75699 | HNBE_control_0h | HNBE_infected_8h | down | -1.98 | 3.62e-11 | RNA-Seq data |
| GSE28166 | mock_infected_18h | VN1203_infected_18h | down | -2.35 | 1.81e-03 | Microarray data |
| GSE28166 | mock_infected_24h | VN1203_infected_24h | down | -2.87 | 1.43e-03 | Microarray data |
| GSE32155 | CRL-5810_unifected | CRL-1472_infected | up | 2.90 | 3.98e-04 | Microarray data |
| GSE32155 | CRL-5810_unifected | CRL-5807_infected | up | 1.72 | 3.87e-03 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_Pan99_pCalu3_24h | down | -1.51 | 2.97e-03 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_VN1203_pCalu3_24h | down | -1.78 | 3.18e-03 | Microarray data |
| GSE97672-GPL16791 | MDM-418_H3N2_MOI0_18h | MDM-418_H3N2_MOI2_18h | down | -1.67 | 1.15e-03 | RNA-Seq data |
| GSE97672-GPL18573 | MDM-513_H5N1_MOI0_12h | MDM-513_H5N1_MOI2_12h | down | -1.52 | 9.44e-03 | RNA-Seq data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Tissue enriched:
| Tissue | Expression (TPM) |
|---|---|
| placenta | 84.6 |
| Ensembl ID: | ENSG00000145604 |
| Gene description: | S-phase kinase associated protein 2 |
| Chromosome: | 5 |
| Position | 36151989-36184319 |
| Protein class: | Cancer-related genes, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleus, Cytosol |