HVIDB-PPI detail

Homo sapiens

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Human protein: SRSF5_HUMAN

UniProtID: Q13243

Gene name(s): SRSF5;HRS;SFRS5;SRP40

Protein name: Serine/arginine-rich splicing factor 5

Gene ID: 6430

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q13243-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
2589	PGC-1-SRp40-SRp55-SRp75 complex	4	0.25 (1/4)	10983978	CORUM	View
351	Spliceosome	143	0.04 (6/143)	12226669	CORUM	View
491	Spliceosome	46	0.07 (3/46)	NA	hu.MAP	View
2802	Spliceosome	41	0.05 (2/41)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE27702	control_macrophages	H5N1-infected_macrophages	down	-1.65	1.15e-02	Microarray data
GSE35473	MOI_uninfected	MOI_influenza_A_infected	down	-1.59	8.23e-03	Microarray data
GSE59226	Control	Virus_infection	down	-2.13	1.88e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-1.57	6.78e-05	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Ensembl ID:	ENSG00000100650
Gene description:	Serine and arginine rich splicing factor 5
Chromosome:	14
Position	69726900-69772005
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleus, Nucleoli