Q12933 (TRAF2)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: TRAF2_HUMAN

UniProtID: Q12933

Gene name(s): TRAF2;TRAP3

Protein name: TNF receptor-associated factor 2

Gene ID: 7186

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q12933-P27958biogrid,HPIDB11821416affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.028). Show
Machine learning evidence: yes (score 0.177).
Combined Score: 0.436


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2744TRAF2-MALT1 complex20.50 (1/2)15125833CORUMView
5210TANK-TRAF2-TRAF3 complex30.33 (1/3)14743216CORUMView
5212Kinase maturation complex 280.50 (4/8)14743216CORUMView
5529TRAF2-cIAP1/BIRC2 complex20.50 (1/2)15861135CORUMView
5531Tumor necrosis factor receptor 1 signaling complex40.50 (2/4)8943045CORUMView
5540TRAF2-TRADD complex20.50 (1/2)12796506CORUMView
5541Ternary complex (TRAF2, FADD, TRADD)30.33 (1/3)12796506CORUMView
6344TNF-R1-associated signaling complex150.33 (5/15)20005846CORUMView
6347TNF-R1 signaling complex50.40 (2/5)8612133CORUMView
4096TRAF2-cIAP1/BIRC2 complex20.50 (1/2)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE102481mock_infected_18hRVFV_MP12_infected_18hdown-2.103.34e-03RNA-Seq data
GSE28166mock_infected_12hVN1203_infected_12hdown-2.964.04e-03Microarray data
GSE28166mock_infected_18hVN1203_infected_18hdown-3.103.93e-03Microarray data
GSE28166mock_infected_24hVN1203_infected_24hdown-1.993.68e-04Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infectedup1.511.66e-04Microarray data
GSE40711mock_infected_6hIDN3006_or_cl2PA_infected_6hdown-2.135.65e-05Microarray data
GSE68503empty_vector_controltumor-derived_LT339up1.551.11e-02Microarray data
GSE68503empty_vector_controltumor-derived_LT339+sTup1.681.24e-02Microarray data
GSE89008HTBE_H5N1_MOI0_mock_infected_6hHTBE_H5N1_MOI5_infected_6hdown-2.545.57e-18RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_06hMDM-418_H3N2_MOI2_06hdown-1.642.27e-04RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_12hMDM-418_H3N2_MOI2_12hdown-1.622.89e-02RNA-Seq data
GSE97672-GPL16791MDM-513_H5N1_MOI0_06hMDM-513_H5N1_MOI2_06hdown-2.871.20e-20RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_06hMDM-520_H5N1_MOI2_06hdown-2.591.88e-20RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hdown-2.037.57e-15RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-1.621.05e-09RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-1.814.64e-11RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_12hMDM-513_H5N1_MOI2_12hdown-2.171.94e-12RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 10.6 Liver: 2.8 Gallbladder: 9.3 Duodenum: 10.2 Rectum: 6.0 Tonsil: 13.6 Stomach: 9.2 Salivary glanda: 5.2 Adipose tissue: 6.1 Lung: 9.5 Lymph node: 22.5 Pancreas: 1.2 Kidney: 3.5 Colon: 7.9 Appendix: 18.3 Smooth musle: 9.1 Breast: 6.9 Parathyroid gland: 8.2 Esophagus: 10.9 Heart muscle: 5.0 Spleen: 17.2 Skeletal muscle: 2.0 Bone marrow: 10.4 Skin: 14.0 Urinary bladder: 9.0 Cervix, uterine: 8.1 Endometrium: 9.7 Ovary: 7.2 Fallopian tube: 12.6 Seminal vesicle: 11.8 Prostate: 10.7 Epididymis: 5.0 Testis: 17.9 Placenta: 12.0 Thyroid gland: 14.8 Cerebral cortex: 8.4 Adrenal gland: 6.8
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000127191
Gene description:TNF receptor associated factor 2
Chromosome:9
Position136881912-136926607
Protein class:Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Cytosol