HVIDB-PPI detail

Q09666 (AHNAK)

Homo sapiens

P27958-PRO_0000037576 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: AHNK_HUMAN

UniProtID: Q09666

Gene name(s): AHNAK;PM227

Protein name: Neuroblast differentiation-associated protein AHNAK

Gene ID: 79026

HDF/HRF: NA

Virus protein: Non-structural protein 5A(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037576

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q09666-P27958-PRO_0000037576	HPIDB	15607035	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	yes (score 0.049).	Show
Machine learning evidence:	yes (score 0.113).

Combined Score: 0.962

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
336	DNA ligase IV-XRCC4-AHNK complex	3	0.33 (1/3)	15177040	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE84897	MKN7_WT_control	MKN7_EBV_infected	up	3.68	2.28e-05	RNA-Seq data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-2.28	2.26e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	down	-2.05	1.15e-02	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	1.97	8.74e-05	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	2.00	8.22e-05	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-1.96	2.66e-03	Microarray data
GSE43794	NPCs_jCV_infection_0h	NPCs_jCV_infection_30d	up	1.92	1.72e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	down	-1.62	1.43e-06	Microarray data
GSE92496	control_vector	HPV16_E6-E7_vector	up	2.96	6.34e-21	RNA-Seq data
GSE93385	K048_mock_infected	K048_ZIKV_infected	up	1.54	3.23e-09	RNA-Seq data
GSE99298	mock_infected_0h	hRSV_WT_infected_96h	up	1.53	6.05e-03	RNA-Seq data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	down	-1.52	5.87e-04	Microarray data
GSE68503	empty_vector_control	tumor-derived_LT339+sT	down	-1.58	1.39e-02	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_6h	HTBE_H5N1_MOI5_infected_6h	down	-2.40	6.47e-35	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-3.39	5.65e-63	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-2.52	9.33e-46	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-2.55	3.01e-53	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-2.44	3.52e-51	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-3.49	1.66e-57	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-3.84	1.69e-129	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000124942
Gene description:	AHNAK nucleoprotein
Chromosome:	11
Position	62433542-62556235
Protein class:	Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Plasma membrane, Cytosol