HVIDB-PPI detail

Q09472 (EP300)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

Networks viewer (Cytoscape.js) and color tagging feature require Firefox or Chrome browsers to work properly

Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: EP300_HUMAN

UniProtID: Q09472

Gene name(s): EP300;P300

Protein name: Histone acetyltransferase p300

Gene ID: 2033

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q09472-P27958	biogrid,HPIDB	15380363	pull down

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.030).	Show
Machine learning evidence:	yes (score 0.339).

Combined Score: 0.924

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1158	p33ING1b-p300 complex	2	0.50 (1/2)	12015309	CORUM	View
1160	ING1-p300-PCNA complex	3	0.33 (1/3)	12015309	CORUM	View
1471	pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300)	5	0.20 (1/5)	12789259	CORUM	View
1521	p300-SMAD1-STAT3 complex	3	0.67 (2/3)	10205054	CORUM	View
1831	PIAS3-SMAD3-P300 complex	3	0.67 (2/3)	14691252	CORUM	View
2638	HES1 promoter corepressor complex	6	0.33 (2/6)	15546612	CORUM	View
2639	HES1 promoter-Notch enhancer complex	13	0.15 (2/13)	15546612	CORUM	View
2642	SMAD1-P300 complex	2	0.50 (1/2)	10673036	CORUM	View
4	Multisubunit ACTR coactivator complex	4	0.50 (2/4)	9267036	CORUM	View
5118	RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2)	6	0.17 (1/6)	12789259	CORUM	View
5260	TCF4-CTNNB1-SUMO1-EP300-HADAC6 complex	5	0.20 (1/5)	15782138	CORUM	View
5261	TCF4-CTNNB1-EP300 complex	3	0.33 (1/3)	15782138	CORUM	View
5375	EGR-EP300 complex	2	0.50 (1/2)	15225550	CORUM	View
570	p300-CBP-p270-SWI/SNF complex	7	0.29 (2/7)	9584200	CORUM	View
571	p300-CBP-p270 complex	3	0.67 (2/3)	8995708	CORUM	View
6354	Sox4-beta-catenin-p300 complex	3	0.33 (1/3)	26841870	CORUM	View
6502	Estrogen receptor complex (ESR1, EP300, NCOA1)	3	0.33 (1/3)	8876171	CORUM	View
6653	EP300-KAT2B-TBX5-WWTR1 complex	4	0.25 (1/4)	16332960	CORUM	View
7328	AML1-HIPK2-p300 complex	3	0.33 (1/3)	16917507	CORUM	View
7581	ESR1-TRAP/Mediator coactivator-complex	18	0.06 (1/18)	11867769	CORUM	View
7582	ESR2-TRAP/Mediator coactivator complex	18	0.06 (1/18)	11867769	CORUM	View
98	p300-MDM2-p53 protein complex	3	0.67 (2/3)	11070080	CORUM	View
2261	p33ING1b-p300 complex	3	0.33 (1/3)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	up	1.77	6.60e-11	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	up	1.84	8.34e-11	RNA-Seq data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-1.57	9.75e-03	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	up	2.01	1.92e-03	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	2.27	1.67e-04	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.70	5.78e-05	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	down	-1.51	2.46e-03	Microarray data
GSE65123	healthy_seronegative_control	HCV_infected	down	-3.76	3.18e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	2.98	3.58e-03	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	1.53	1.70e-12	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000100393
Gene description:	E1A binding protein p300
Chromosome:	22
Position	41091786-41180079
Protein class:	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm