HVIDB-PPI detail

Q06278 (AOX1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: AOXA_HUMAN

UniProtID: Q06278

Gene name(s): AOX1;AO

Protein name: Aldehyde oxidase

Gene ID: 316

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q06278-P27958	biogrid,HPIDB	26845356	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.049).

Combined Score: 0.027

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1001	Prefoldin complex	6	0.17 (1/6)	NA	hu.MAP	View
1934	Prefoldin complex	8	0.25 (2/8)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE79968	IMR90_GFP_32h	IMR90_MCPyV_ST_32h	up	2.05	1.67e-03	RNA-Seq data
GSE83525	B19_NS1_unexpressed	B19_NS1_expressed	up	5.77	6.77e-03	RNA-Seq data
GSE84897	MKN7_WT_control	MKN7_EBV_infected	up	3.22	3.19e-03	RNA-Seq data
GSE1377	uninfected_control	KSHV_infected	down	-2.89	4.39e-02	Microarray data
GSE20948	Huh7_mock_infected_48h	Huh7_JFH-1_infected_48h	up	1.60	1.90e-06	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	up	2.43	1.70e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	up	2.66	1.64e-02	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	2.35	5.00e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-4.34	1.58e-06	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	down	-2.99	2.27e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-4.96	1.10e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	down	-3.60	2.52e-04	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-4.01	7.33e-03	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-3.32	2.58e-02	Microarray data
GSE38941	nomal_liver	HBV-associated_acute_liver_failure_liver	down	-4.66	1.11e-07	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	up	2.57	2.34e-03	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	1.58	4.90e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Anhui01_pCalu3_12h	up	1.65	9.66e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_NL219_pCalu3_12h	up	2.46	3.39e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	up	3.79	1.45e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	1.96	3.95e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	up	3.74	2.06e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	2.42	2.19e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	4.66	5.24e-07	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-2.20	2.07e-05	Microarray data
GSE64605	HS_unifected	HS_Q70_or_M91_infected	up	2.05	8.87e-06	Microarray data
GSE64605	HS_unifected	HS_R70_or_L91_infected	up	1.76	1.43e-05	Microarray data
GSE97949	uninfected_0h	H7N9_infected_7h	down	-2.00	2.73e-39	RNA-Seq data
GSE68503	empty_vector_control	tumor-derived_LT339+sT	up	3.04	1.61e-02	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	up	2.42	4.55e-02	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	3.71	1.71e-05	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	1.64	5.60e-06	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	1.84	3.31e-04	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	3.46	7.17e-09	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	4.38	1.97e-10	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Group enriched:

Tissue	Expression (TPM)
adrenal gland	368.8
kidney	97.5
liver	432.3

Ensembl ID:	ENSG00000138356
Gene description:	Aldehyde oxidase 1
Chromosome:	2
Position	200585868-200677064
Protein class:	Enzymes, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location: