HVIDB-PPI detail

Q06033 (ITIH3)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: ITIH3_HUMAN

UniProtID: Q06033

Gene name(s): ITIH3

Protein name: Inter-alpha-trypsin inhibitor heavy chain H3

Gene ID: 3699

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q06033-P27958	biogrid,HPIDB	26845356	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.002).	Show
Machine learning evidence:	yes (score 0.073).

Combined Score: 0.042

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE84188	mock_infected_1d	EBOV_infected_1d	up	6.46	3.50e-03	RNA-Seq data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	2.56	2.47e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-2.29	1.96e-03	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	down	-2.12	3.50e-03	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	up	1.72	6.07e-03	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	up	1.89	3.19e-03	Microarray data
GSE38941	nomal_liver	HBV-associated_acute_liver_failure_liver	down	-2.98	1.43e-04	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	4.15	3.75e-03	Microarray data
GSE97949	uninfected_0h	H7N9_infected_7h	up	6.48	6.76e-03	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	up	8.18	7.00e-04	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	4.35	2.93e-03	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	7.70	2.39e-03	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	8.15	1.36e-03	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	7.92	4.49e-04	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	7.72	3.24e-04	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_03h	MDM-418_H3N2_MOI2_03h	up	5.24	6.96e-04	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	9.75	8.94e-09	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	up	6.10	6.03e-07	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	6.25	6.97e-17	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	up	8.66	4.96e-06	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	3.60	5.52e-06	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	7.95	6.00e-18	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	7.48	1.42e-12	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	11.14	1.52e-11	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	9.66	1.54e-08	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enriched:

Tissue	Expression (TPM)
liver	413.6

Ensembl ID:	ENSG00000162267
Gene description:	Inter-alpha-trypsin inhibitor heavy chain 3
Chromosome:	3
Position	52794768-52809009
Protein class:	Plasma proteins, Predicted secreted proteins
Evidence:	Evidence at protein level
Subcellular location: