HVIDB-PPI detail

P68371 (TUBB4B)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

Networks viewer (Cytoscape.js) and color tagging feature require Firefox or Chrome browsers to work properly

Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: TBB4B_HUMAN

UniProtID: P68371

Gene name(s): TUBB4B;TUBB2C

Protein name: Tubulin beta-4B chain

Gene ID: 10383

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P68371-P27958	PHISTO,biogrid,HPIDB,VirusMentha	22810585	affinity chromatography technology,tandem affinity purification

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.999).	Show
DDI evidence:	yes (score 0.029).	Show
Machine learning evidence:	yes (score 0.229).

Combined Score: 0.997

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
2647	Tubulin alpha/beta chain	2	0.50 (1/2)	NA	hu.MAP	View
3231	ribonucleoside binding	4	0.50 (2/4)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-1.76	9.92e-05	RNA-Seq data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-1.79	1.57e-02	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-2.03	2.44e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-2.07	1.61e-03	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-1.92	3.76e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-2.39	6.29e-06	Microarray data
GSE36553	mock_infection	H1N1_infection_72h	down	-1.89	1.37e-02	Microarray data
GSE36555	mock_infection	H1N1_infection_72h	down	-1.89	1.37e-02	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.51	7.61e-05	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group1	down	-2.09	1.39e-06	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group2	down	-1.57	1.80e-06	Microarray data
GSE49628	Bcells_Quiescent	Bcells_Activation	up	1.67	2.03e-04	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	up	1.99	8.40e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.89	1.63e-05	Microarray data
GSE65574	MCL001_mock_0h	MCL001_d3-5-MERS_0h	down	-3.18	3.22e-02	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-3.35	1.43e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-5.25	1.24e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-6.50	9.08e-06	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-3.27	1.26e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-1.65	2.18e-03	Microarray data
GSE99298	mock_infected_0h	hRSV_NS1_Y125A_infected_96h	up	6.43	7.96e-20	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.46	1.61e-42	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.29	1.10e-52	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-2.49	5.83e-48	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-1.81	3.12e-25	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000188229
Gene description:	Tubulin beta 4B class IVb
Chromosome:	9
Position	137241213-137243707
Protein class:	FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Microtubules