P62993 (GRB2)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: GRB2_HUMAN

UniProtID: P62993

Gene name(s): GRB2;ASH

Protein name: Growth factor receptor-bound protein 2

Gene ID: 2885

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P62993-P27958PHISTO,biogrid,HPIDB,VirusMentha15784897,25872741,14993658affinity chromatography technology,pull down

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 1.000). Show
DDI evidence: yes (score 0.079). Show
Machine learning evidence: yes (score 0.191).
Combined Score: 0.999


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2480CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1)70.14 (1/7)11071869CORUMView
2529LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated70.14 (1/7)9489702CORUMView
2534Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated30.33 (1/3)9716598CORUMView
2535SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated40.25 (1/4)9716598CORUMView
2536PLC-gamma-2-SLP-76-Lyn-Grb2 complex40.50 (2/4)10469124CORUMView
2540BCR-ABL (p210 fusion protein)-GRB2 complex20.50 (1/2)8112292CORUMView
2542EGFR-CBL-GRB2 complex30.33 (1/3)15782196CORUMView
2892BCR-ABL (p185 fusion protein)-GRB2 complex20.50 (1/2)8112292CORUMView
2893BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex30.33 (1/3)8112292CORUMView
2895SHC-GRB2 complex20.50 (1/2)8112292CORUMView
2917GRB2-SOS1 complex20.50 (1/2)9716598CORUMView
2922LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated50.20 (1/5)9489702CORUMView
2957LAT-GRB2 complex, Fyn-mLck(KA) or Syk kinase activated20.50 (1/2)16938345CORUMView
3096ITGA6-ITGB4-SHC1-GRB2 complex40.25 (1/4)7556090CORUMView
3144GRB2-SOS1 complex20.50 (1/2)11777939CORUMView
3186GRB2-SHP-2 complex, PDGF stimulated20.50 (1/2)8943348CORUMView
3970BCR-ABL (p210 fusion protein)-GRB2 complex40.25 (1/4)NAhu.MAPView
4543BCR-ABL (p210 fusion protein)-GRB2 complex20.50 (1/2)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE65123healthy_seronegative_controlHCV_infecteddown-5.014.55e-02Microarray data
GSE65574MCL001_mock_0hMCL001_RFP-MERS_0hdown-2.121.06e-02Microarray data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-1.857.52e-33RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-1.911.36e-32RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 67.8 Liver: 23.6 Gallbladder: 68.1 Duodenum: 57.9 Rectum: 58.0 Tonsil: 98.6 Stomach: 42.6 Salivary glanda: 18.0 Adipose tissue: 64.6 Lung: 99.0 Lymph node: 136.5 Pancreas: 6.8 Kidney: 50.4 Colon: 54.4 Appendix: 134.6 Smooth musle: 85.9 Breast: 42.3 Parathyroid gland: 64.1 Esophagus: 52.1 Heart muscle: 37.0 Spleen: 119.2 Skeletal muscle: 17.0 Bone marrow: 80.6 Skin: 43.2 Urinary bladder: 68.9 Cervix, uterine: 48.2 Endometrium: 63.3 Ovary: 49.2 Fallopian tube: 61.5 Seminal vesicle: 64.4 Prostate: 64.2 Epididymis: 38.5 Testis: 36.2 Placenta: 93.5 Thyroid gland: 63.2 Cerebral cortex: 121.1 Adrenal gland: 67.4
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000177885
Gene description:Growth factor receptor bound protein 2
Chromosome:17
Position75318076-75405709
Protein class:Cancer-related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Evidence:Evidence at protein level
Subcellular location:Nucleus