HVIDB-PPI detail

Homo sapiens

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Human protein: RS28_HUMAN

UniProtID: P62857

Gene name(s): RPS28

Protein name: 40S ribosomal protein S28

Gene ID: 6234

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P62857-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
305	40S ribosomal subunit, cytoplasmic	33	0.06 (2/33)	14681386	CORUM	View
306	Ribosome, cytoplasmic	80	0.10 (8/80)	14681386	CORUM	View
338	40S ribosomal subunit, cytoplasmic	31	0.06 (2/31)	15883184	CORUM	View
3793	nucleic acid binding	10	0.30 (3/10)	NA	hu.MAP	View
3903	LRP4-BEND7-RPS28	3	0.33 (1/3)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-2.27	3.72e-03	RNA-Seq data
GSE59226	Control	Virus_infection	up	2.57	1.02e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-1.52	4.99e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-1.54	1.63e-02	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Ensembl ID:	ENSG00000233927
Gene description:	Ribosomal protein S28
Chromosome:	19
Position	8321158-8323340
Protein class:	Disease related genes, Predicted intracellular proteins, Ribosomal proteins
Evidence:	Evidence at protein level
Subcellular location:	Cytosol