HVIDB-PPI detail

P61964 (WDR5)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

Networks viewer (Cytoscape.js) and color tagging feature require Firefox or Chrome browsers to work properly

Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: WDR5_HUMAN

UniProtID: P61964

Gene name(s): WDR5;BIG3

Protein name: WD repeat-containing protein 5

Gene ID: 11091

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P61964-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.243).

Combined Score: 0.406

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1254	Menin-associated histone methyltransferase complex	7	0.14 (1/7)	14992727	CORUM	View
1256	MLL-HCF complex	7	0.14 (1/7)	15199122	CORUM	View
1257	ALL-1 supercomplex	28	0.07 (2/28)	12453419	CORUM	View
1399	WDR5-ASH2L-RBBP5-MLL2 complex	4	0.25 (1/4)	15960974	CORUM	View
1401	MOF complex	10	0.10 (1/10)	15960975	CORUM	View
2721	HCF-1 complex	18	0.17 (3/18)	12670868	CORUM	View
2730	Set1B complex	6	0.17 (1/6)	17355966	CORUM	View
2731	Set1A complex	6	0.17 (1/6)	17355966	CORUM	View
3075	UTX-MLL2/3 complex	12	0.08 (1/12)	17761849	CORUM	View
5195	PTIP-HMT complex	10	0.10 (1/10)	17500065	CORUM	View
5386	MLL1-WDR5 complex	27	0.04 (1/27)	15960975	CORUM	View
6457	MLL1 core complex	4	0.25 (1/4)	22665483	CORUM	View
6460	MLL2 complex	10	0.10 (1/10)	23508102	CORUM	View
6461	MLL3 complex	9	0.11 (1/9)	23508102	CORUM	View
6462	MLL1 complex	8	0.12 (1/8)	23508102	CORUM	View
6467	MLL4 complex	9	0.11 (1/9)	23508102	CORUM	View
6469	Set1A complex	10	0.10 (1/10)	23508102	CORUM	View
6470	Set1B complex	12	0.08 (1/12)	23508102	CORUM	View
6489	CUL4A-DDB1-WDR5 complex	3	0.67 (2/3)	17041588	CORUM	View
6657	ATAC complex, GCN5-linked	10	0.10 (1/10)	26468280	CORUM	View
6665	ATAC complex, YEATS2-linked	14	0.07 (1/14)	18838386	CORUM	View
6845	NIF1-ASH2L-RBBP5-WDR5 complex	4	0.25 (1/4)	19131338	CORUM	View
6849	WRAD complex (WDR5, RBBP5, ASH2L, DPY30)	4	0.25 (1/4)	21106533	CORUM	View
6850	WRA complex (WDR5, RBBP5, ASH2L)	3	0.33 (1/3)	21106533	CORUM	View
6851	MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30)	5	0.20 (1/5)	21106533	CORUM	View
7221	NSL complex	9	0.22 (2/9)	20018852	CORUM	View
7367	ASH2L-KDM6B-KDM6B-WDR5 complex	4	0.25 (1/4)	17825402	CORUM	View
1082	MLL1 core complex	4	0.25 (1/4)	NA	hu.MAP	View
1588	PTIP-HMT complex	9	0.11 (1/9)	NA	hu.MAP	View
1931	Set1B complex	10	0.10 (1/10)	NA	hu.MAP	View
2090	MLL4 complex	4	0.25 (1/4)	NA	hu.MAP	View
3316	PTIP-HMT complex	4	0.25 (1/4)	NA	hu.MAP	View
3466	MLL3 complex	4	0.25 (1/4)	NA	hu.MAP	View
3470	MLL4 complex	11	0.09 (1/11)	NA	hu.MAP	View
3481	MLL4 complex	4	0.25 (1/4)	NA	hu.MAP	View
3574	Set1B complex	6	0.17 (1/6)	NA	hu.MAP	View
3595	MLL3 complex	4	0.25 (1/4)	NA	hu.MAP	View
4173	MLL4 complex	4	0.25 (1/4)	NA	hu.MAP	View
4532	MLL4 complex	4	0.25 (1/4)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.53	1.37e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-1.53	4.05e-05	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-1.72	1.17e-08	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-2.30	5.17e-04	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-1.81	1.29e-12	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-1.70	9.73e-12	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.53	1.12e-13	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-2.21	2.71e-08	RNA-Seq data
GSE93861	healthy_blood_control	Ebola_infection	up	1.50	1.26e-11	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000196363
Gene description:	WD repeat domain 5
Chromosome:	9
Position	134135365-134159968
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm