P61289 (PSME3)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: PSME3_HUMAN

UniProtID: P61289

Gene name(s): PSME3

Protein name: Proteasome activator complex subunit 3

Gene ID: 10197

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P61289-P27958biogrid,HPIDB18985028two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.947). Show
DDI evidence: yes (score 0.179). Show
Machine learning evidence: yes (score 0.219).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
194PA28gamma-20S proteasome150.20 (3/15)7811265CORUMView
29PA28gamma complex11.00 (1/1)9325261CORUMView
257PA28gamma complex70.29 (2/7)NAhu.MAPView
1104PA28gamma complex40.25 (1/4)NAhu.MAPView
1241PA28gamma complex60.33 (2/6)NAhu.MAPView
1678PA28gamma complex40.25 (1/4)NAhu.MAPView
2846PA28gamma complex30.33 (1/3)NAhu.MAPView
4055PA28gamma complex40.50 (2/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE78711-GPL18573NPC_mock_infectedNPC_Zika_infecteddown-1.685.24e-50RNA-Seq data
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_DeltaE_15hpidown-1.821.01e-06Microarray data
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_WT_15hpidown-2.001.39e-06Microarray data
GSE49628Bcells_QuiescentBcells_EBV_transformedup1.585.46e-03Microarray data
GSE59226ControlVirus_infectiondown-1.772.20e-04Microarray data
GSE65574MCL001_mock_0hMCL001_RFP-MERS_0hdown-1.741.16e-02Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-2.548.12e-05Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-1.721.13e-02Microarray data
GSE65574MCL001_mock_7hMCL001_RFP-MERS_7hdown-2.198.08e-04Microarray data
GSE99298mock_infected_0hhRSV_NS1_Y125A_infected_96hup1.841.63e-02RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-1.732.01e-06RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 52.4 Liver: 22.1 Gallbladder: 63.6 Duodenum: 49.3 Rectum: 62.9 Tonsil: 68.7 Stomach: 46.4 Salivary glanda: 18.7 Adipose tissue: 64.3 Lung: 60.9 Lymph node: 76.2 Pancreas: 11.3 Kidney: 64.3 Colon: 53.1 Appendix: 73.5 Smooth musle: 76.5 Breast: 53.7 Parathyroid gland: 106.3 Esophagus: 70.3 Heart muscle: 34.2 Spleen: 59.4 Skeletal muscle: 21.7 Bone marrow: 38.0 Skin: 51.3 Urinary bladder: 67.9 Cervix, uterine: 65.5 Endometrium: 66.4 Ovary: 32.0 Fallopian tube: 71.5 Seminal vesicle: 65.6 Prostate: 68.1 Epididymis: 40.1 Testis: 101.7 Placenta: 67.9 Thyroid gland: 89.5 Cerebral cortex: 77.0 Adrenal gland: 51.6
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000131467
Gene description:Proteasome activator subunit 3
Chromosome:17
Position42824385-42843758
Protein class:Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm