P60174 (TPI1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: TPIS_HUMAN

UniProtID: P60174

Gene name(s): TPI1;TPI

Protein name: Triosephosphate isomerase

Gene ID: 7167

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P60174-P27958PHISTO,biogrid,HPIDB,VirusMentha22810585affinity chromatography technology,tandem affinity purification

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: yes (score 0.028). Show
Machine learning evidence: yes (score 0.083).
Combined Score: 0.861


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
50YDJC-TPI1-TKT-PCMT1-ENO150.40 (2/5)NAhu.MAPView
645WDR1-FH-TPI130.33 (1/3)NAhu.MAPView
1084TPI1-GAPDH-ENO1-PCMT1-TKT50.40 (2/5)NAhu.MAPView
2111TPI1-ENO121.00 (2/2)NAhu.MAPView
3167PGK1-GAPDH-ENO3-TPI140.25 (1/4)NAhu.MAPView
3740ENO1-CMPK1-TPI130.67 (2/3)NAhu.MAPView
4017FH-HSD17B14-ABAT-SOD1-TPI1-WDR160.17 (1/6)NAhu.MAPView
4202NIT2-GAPDH-ENO1-TPI1-PCMT150.40 (2/5)NAhu.MAPView
4540Sorcin homodimer complex80.25 (2/8)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE48121PANC-1_cells_controlPANC-1_cells_GLV-1h153_infection_6hdown-1.522.26e-07Microarray data
GSE49628Bcells_QuiescentBcells_EBV_transformedup1.651.22e-04Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hdown-3.045.07e-04Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-3.152.77e-05Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-1.601.11e-02Microarray data
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hdown-2.604.34e-04Microarray data
GSE65574MCL001_mock_24hMCL001_d4B-MERS_24hdown-2.768.19e-04Microarray data
GSE65574MCL001_mock_24hMCL001_RFP-MERS_24hdown-1.601.01e-02Microarray data
GSE65574MCL001_mock_7hMCL001_RFP-MERS_7hdown-1.691.60e-02Microarray data
GSE99298mock_infected_0hhRSV_NS1_L132A_L133A_infected_96hup7.859.39e-04RNA-Seq data
GSE99298mock_infected_0hhRSV_NS1_Y125A_infected_96hup6.491.29e-11RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 494.4 Liver: 244.2 Gallbladder: 384.5 Duodenum: 468.2 Rectum: 533.8 Tonsil: 415.2 Stomach: 226.4 Salivary glanda: 100.8 Adipose tissue: 274.5 Lung: 312.2 Lymph node: 326.0 Pancreas: 37.4 Kidney: 514.0 Colon: 452.4 Appendix: 402.3 Smooth musle: 489.2 Breast: 280.2 Parathyroid gland: 561.5 Esophagus: 507.8 Heart muscle: 425.0 Spleen: 237.6 Skeletal muscle: 942.7 Bone marrow: 231.4 Skin: 307.0 Urinary bladder: 316.8 Cervix, uterine: 437.9 Endometrium: 302.9 Ovary: 203.1 Fallopian tube: 399.6 Seminal vesicle: 429.8 Prostate: 342.0 Epididymis: 301.2 Testis: 301.3 Placenta: 453.7 Thyroid gland: 384.1 Cerebral cortex: 619.5 Adrenal gland: 451.8
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000111669
Gene description:Triosephosphate isomerase 1
Chromosome:12
Position6867119-6870948
Protein class:Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm