P55036 (PSMD4)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: PSMD4_HUMAN

UniProtID: P55036

Gene name(s): PSMD4;MCB1

Protein name: 26S proteasome non-ATPase regulatory subunit 4

Gene ID: 5710

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P55036-P27958-PRO_0000037566HPIDB23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.461).
Combined Score: 0.962


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
18126S proteasome220.14 (3/22)11812135CORUMView
193PA700-20S-PA28 complex360.08 (3/36)11676531CORUMView
32PA700 complex200.05 (1/20)9148964CORUMView
768PA700 complex270.07 (2/27)NAhu.MAPView
1639PA700 complex300.10 (3/30)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_DeltaE_15hpidown-2.194.53e-07Microarray data
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_WT_15hpidown-2.218.03e-07Microarray data

Human tissue specific expression (TPM)

Small intestine: 68.8 Liver: 68.1 Gallbladder: 88.3 Duodenum: 67.9 Rectum: 88.4 Tonsil: 100.7 Stomach: 58.0 Salivary glanda: 33.8 Adipose tissue: 94.5 Lung: 89.6 Lymph node: 105.5 Pancreas: 17.2 Kidney: 77.5 Colon: 78.4 Appendix: 102.7 Smooth musle: 130.1 Breast: 106.5 Parathyroid gland: 122.4 Esophagus: 84.6 Heart muscle: 76.3 Spleen: 99.7 Skeletal muscle: 92.5 Bone marrow: 54.8 Skin: 98.6 Urinary bladder: 84.1 Cervix, uterine: 90.3 Endometrium: 108.7 Ovary: 90.9 Fallopian tube: 143.7 Seminal vesicle: 118.5 Prostate: 104.3 Epididymis: 140.0 Testis: 174.0 Placenta: 127.5 Thyroid gland: 95.0 Cerebral cortex: 134.5 Adrenal gland: 90.3
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000159352
Gene description:Proteasome 26S subunit, non-ATPase 4
Chromosome:1
Position151254703-151267479
Protein class:Cancer-related genes, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Cytosol