Human protein: PSMD4_HUMAN
UniProtID: P55036
Gene name(s): PSMD4;MCB1
Protein name: 26S proteasome non-ATPase regulatory subunit 4
Gene ID: 5710
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| P55036-P27958 | PHISTO | 23487458 | protein array |
| Interolog evidence: | none/insignificant. |
| DDI evidence: | none/insignificant. |
| Machine learning evidence: | yes (score 0.173). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 181 | 26S proteasome | 22 | 0.14 (3/22) | 11812135 | CORUM | View |
| 193 | PA700-20S-PA28 complex | 36 | 0.08 (3/36) | 11676531 | CORUM | View |
| 32 | PA700 complex | 20 | 0.05 (1/20) | 9148964 | CORUM | View |
| 768 | PA700 complex | 27 | 0.07 (2/27) | NA | hu.MAP | View |
| 1639 | PA700 complex | 30 | 0.10 (3/30) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE30589 | Vero_E6_Mock_infected_15hpi | Vero_E6_SARS-Cov_DeltaE_15hpi | down | -2.19 | 4.53e-07 | Microarray data |
| GSE30589 | Vero_E6_Mock_infected_15hpi | Vero_E6_SARS-Cov_WT_15hpi | down | -2.21 | 8.03e-07 | Microarray data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000159352 |
| Gene description: | Proteasome 26S subunit, non-ATPase 4 |
| Chromosome: | 1 |
| Position | 151254703-151267479 |
| Protein class: | Cancer-related genes, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleoplasm, Cytosol |