P54274 (TERF1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: TERF1_HUMAN

UniProtID: P54274

Gene name(s): TERF1;PIN2;TRBF1;TRF;TRF1

Protein name: Telomeric repeat-binding factor 1

Gene ID: 7013

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P54274-P27958PHISTO23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.011). Show
Machine learning evidence: yes (score 0.083).
Combined Score: 0.071


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1197Telomere-associated protein complex60.17 (1/6)15181449CORUMView
1201TRF1-TIN2 complex40.25 (1/4)15231715CORUMView
1202TRF1 telomere length regulation complex30.33 (1/3)15133513CORUMView
1204Rap1 complex70.14 (1/7)15316005CORUMView
1206TRF-Rap1 complex I, 2MD60.17 (1/6)15316005CORUMView
1219Tankyrin 1-tankyrin 2-TRF1 complex30.33 (1/3)12080061CORUMView
138Telomere-associated protein complex60.17 (1/6)15383534CORUMView
2219TERF1 homodimer complex11.00 (1/1)9391075CORUMView
15TERF1 homodimer complex20.50 (1/2)NAhu.MAPView
3878Telomere-associated protein complex70.14 (1/7)NAhu.MAPView
4527TRF1-TIN2 complex40.25 (1/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE32155CRL-5810_unifectedCRL-1472_infectedup1.505.56e-05Microarray data

Human tissue specific expression (TPM)

Small intestine: 15.2 Liver: 10.7 Gallbladder: 22.1 Duodenum: 13.8 Rectum: 16.2 Tonsil: 14.0 Stomach: 18.4 Salivary glanda: 7.0 Adipose tissue: 18.9 Lung: 20.1 Lymph node: 21.2 Pancreas: 2.7 Kidney: 26.6 Colon: 14.0 Appendix: 16.8 Smooth musle: 25.3 Breast: 20.7 Parathyroid gland: 39.0 Esophagus: 15.9 Heart muscle: 11.9 Spleen: 19.0 Skeletal muscle: 3.8 Bone marrow: 18.3 Skin: 12.1 Urinary bladder: 21.3 Cervix, uterine: 24.6 Endometrium: 35.7 Ovary: 37.0 Fallopian tube: 28.7 Seminal vesicle: 28.0 Prostate: 37.4 Epididymis: 17.8 Testis: 30.4 Placenta: 23.2 Thyroid gland: 35.4 Cerebral cortex: 45.8 Adrenal gland: 28.3
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000147601
Gene description:Telomeric repeat binding factor 1
Chromosome:8
Position73008864-73048122
Protein class:Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoli fibrillar center, Nuclear bodies