P42356 (PI4KA)

Homo sapiens

P27958-PRO_0000037576 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: PI4KA_HUMAN

UniProtID: P42356

Gene name(s): PI4KA;PIK4;PIK4CA

Protein name: Phosphatidylinositol 4-kinase alpha

Gene ID: 5297

HDF/HRF: NA

Virus protein: Non-structural protein 5A(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037576

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P42356-P27958-PRO_0000037576HPIDB21297162anti bait coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.977). Show
DDI evidence: yes (score 0.013). Show
Machine learning evidence: yes (score 0.725).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
6890Phosphatidylinositol 4-kinase complex40.25 (1/4)26571211CORUMView
725P2X7 receptor signalling complex120.25 (3/12)11707406CORUMView
248PI4KA-CAND2-HEATR130.33 (1/3)NAhu.MAPView
742PI4KA-CAND2-NF1-HEATR140.25 (1/4)NAhu.MAPView
1879FASTKD1-PI4KA-CAND2-HEATR1-NF1-MON260.17 (1/6)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE32140-GPL6480mock_for_RSV_2hRSV_infectiondown-1.581.61e-04Microarray data
GSE40711mock_infected_6hIDN3006_or_cl2PA_infected_6hdown-1.532.38e-04Microarray data
GSE97672-GPL16791MDM-418_H3N2_MOI0_06hMDM-418_H3N2_MOI2_06hdown-1.981.16e-24RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_12hMDM-418_H3N2_MOI2_12hdown-1.973.50e-04RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_18hMDM-418_H3N2_MOI2_18hdown-2.441.58e-34RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hdown-2.339.16e-39RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-2.432.66e-41RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-2.511.41e-34RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 19.4 Liver: 5.8 Gallbladder: 21.3 Duodenum: 15.9 Rectum: 16.4 Tonsil: 16.5 Stomach: 16.3 Salivary glanda: 5.3 Adipose tissue: 15.6 Lung: 23.3 Lymph node: 24.4 Pancreas: 2.3 Kidney: 14.4 Colon: 15.2 Appendix: 25.7 Smooth musle: 32.4 Breast: 13.6 Parathyroid gland: 66.0 Esophagus: 15.4 Heart muscle: 9.8 Spleen: 25.5 Skeletal muscle: 4.8 Bone marrow: 15.6 Skin: 13.7 Urinary bladder: 17.1 Cervix, uterine: 23.4 Endometrium: 26.8 Ovary: 20.3 Fallopian tube: 22.6 Seminal vesicle: 23.5 Prostate: 25.9 Epididymis: 12.0 Testis: 43.2 Placenta: 25.7 Thyroid gland: 27.9 Cerebral cortex: 113.6 Adrenal gland: 19.8
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000241973
Gene description:Phosphatidylinositol 4-kinase alpha
Chromosome:22
Position20707691-20859417
Protein class:Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Plasma membrane