HVIDB-PPI detail

P42224 (STAT1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: STAT1_HUMAN

UniProtID: P42224

Gene name(s): STAT1

Protein name: Signal transducer and activator of transcription 1-alpha/beta

Gene ID: 6772

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P42224-P27958	PHISTO	15825084	anti bait coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	yes (score 0.213).	Show
Machine learning evidence:	yes (score 0.280).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
5573	Stat1-alpha-dimer-CBP DNA-protein complex	2	1.00 (2/2)	8986769	CORUM	View
60	Interferon-stimulated gene factor 3 transcription complex ISGF3	3	0.33 (1/3)	8943351	CORUM	View
7385	DTX3L-PARP9-STAT1 complex	3	0.33 (1/3)	26479788	CORUM	View
3372	Stat1-alpha-dimer-CBP DNA-protein complex	4	0.25 (1/4)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE67198	uninfected_control	1.5HA_u_per_mL_Sev_infected	up	3.19	2.00e-09	Microarray data
GSE101760	control_infected	PR8_NS1_infected	up	3.66	1.78e-11	RNA-Seq data
GSE101760	mock_infected	PR8_NS1_infected	up	3.40	1.55e-10	RNA-Seq data
GSE102924	control	ZIKV-Brazil_Dakar_strains	up	2.17	9.09e-11	RNA-Seq data
GSE61141	non-asthmatic_Vehicle	non-asthmatic_HRV16	up	3.42	2.57e-37	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_24h	up	3.40	3.50e-230	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_8h	up	1.64	2.53e-51	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	2.65	1.86e-11	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	2.38	3.19e-27	RNA-Seq data
GSE84346	uninfected_control	HCV_infected_high_ISG	up	2.82	3.68e-27	RNA-Seq data
GSE84346	uninfected_control	HCV_infected_low_ISG	up	1.87	2.95e-07	RNA-Seq data
GSE13637	HUVEC_control	FPV-infected_pEGZ-transfected_HUVEC	up	1.95	5.50e-06	Microarray data
GSE13637	HUVEC_control	H5N1-infected_HUVEC	up	1.68	4.57e-04	Microarray data
GSE13637	HUVEC_control	H5N1-infected_pEGZ-transfected_HUVEC	up	1.79	1.55e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_HUVEC	up	1.62	1.61e-03	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	1.77	9.16e-05	Microarray data
GSE14816	TB40E_mock	TB40E_TB	up	1.66	1.66e-02	Microarray data
GSE15810	hMSCs_mock-transduced	hMSCs_BV-transduced	up	2.45	1.06e-03	Microarray data
GSE24238	Mock_24h	HCMV_24h	up	3.61	1.03e-03	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-1.58	2.55e-03	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-1.62	2.66e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-1.91	4.14e-06	Microarray data
GSE30719	uninfected_primary_RPE	WNV_infected_primary_RPE_24h	up	2.61	6.67e-06	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	2.70	3.85e-05	Microarray data
GSE31193	control	IFN_24h	up	1.80	8.09e-06	Microarray data
GSE31193	control	IFN_6h	up	2.29	9.31e-08	Microarray data
GSE31193	control	IL2B_24h	up	2.88	9.05e-08	Microarray data
GSE31193	control	IL2B_6h	up	2.20	1.70e-06	Microarray data
GSE59226	Control	Inactivate	up	2.27	1.59e-05	Microarray data
GSE31524	H9N2_Mock_infection	H9N2_infection_10h	up	1.63	1.07e-06	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	3.85	1.22e-07	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	3.18	1.03e-06	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	3.29	4.32e-04	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	3.53	1.75e-04	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	down	-1.60	1.07e-07	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	up	3.29	5.53e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Anhui01_pCalu3_12h	up	2.54	2.36e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_NL219_pCalu3_12h	up	2.53	6.73e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	up	3.41	2.01e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_VN1203_pCalu3_12h	up	2.26	1.04e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	1.73	3.27e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	up	2.72	6.29e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	3.64	6.52e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	3.03	1.29e-07	Microarray data
GSE53103	HeLa_no_infection	Hela_SV_12h	up	1.99	1.36e-07	Microarray data
GSE53103	Namalwa_no_infection	Namalwa_SV_6h	up	2.09	1.42e-07	Microarray data
GSE53103	Namalwa_shmH2A1	Namalwa_shmH2A1_+SV_6h	up	3.75	5.08e-03	Microarray data
GSE53543	uninfected_control	RV_infected	up	1.56	2.50e-67	Microarray data
GSE54293	NCI-H1666_mock	NCI-H1666_infected	up	3.04	7.41e-08	Microarray data
GSE54648	mock_infected_1dpi	HCV_infected_1dpi	up	1.55	1.15e-06	Microarray data
GSE57647	Mock_infection_24h	JEV_infection_24h	up	2.73	2.16e-07	Microarray data
GSE57647	Mock_infection_48h	JEV_infection_48h	up	1.89	7.40e-04	Microarray data
GSE93385	K054_mock_infected	K054_ZIKV_infected	up	2.80	6.73e-120	RNA-Seq data
GSE58278	MDDCs_unifected_0h	MDDCs_Dengue_infected_18h	up	2.01	1.24e-03	Microarray data
GSE58278	MDDCs_unifected_0h	MDDCs_Dengue_infected_24h	up	2.46	1.81e-04	Microarray data
GSE93385	K048_mock_infected	K048_ZIKV_infected	up	3.86	1.13e-110	RNA-Seq data
GSE97949	uninfected_0h	H7N9_infected_7h	down	-1.92	3.71e-55	RNA-Seq data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-2.25	1.33e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-1.54	3.67e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	4.19	1.14e-04	Microarray data
GSE99298	mock_infected_0h	hRSV_WT_infected_96h	up	2.39	2.96e-05	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	up	2.08	1.01e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	up	2.51	3.65e-03	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	2.78	6.34e-22	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	3.52	1.17e-02	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-2.60	1.64e-03	Microarray data
GSE65699	PRE_mock	PRE_infection_RKAA	up	3.14	1.76e-13	Microarray data
GSE65699	PRE_mock	PRE_infection_WT	up	3.46	3.63e-14	Microarray data
GSE87750-GPL16791	hNCC_mock_infected	hNCC_ZIKV-PRVABC59_infected	up	1.55	1.29e-06	RNA-Seq data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	up	2.25	1.16e-02	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	1.96	1.91e-02	Microarray data
GSE67198	uninfected_control	150HA_u_per_mL_Sev_infected	up	2.03	3.86e-08	Microarray data
GSE87750-GPL16791	hPN_mock_infected	hPN_ZIKV-PRVABC59_infected	up	1.70	2.98e-06	RNA-Seq data
GSE71766	BEAS-2B_control_24hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_24hrs	up	3.24	2.58e-14	Microarray data
GSE71766	BEAS-2B_control_24hrs	BEAS-2B_InfluenzaVirus_24hrs	up	3.36	1.74e-15	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	up	2.73	1.02e-74	RNA-Seq data
GSE71766	BEAS-2B_control_36hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_36hrs	up	3.40	1.80e-15	Microarray data
GSE89008	HTBE_H3N2_MOI0_mock_infected_6h	HTBE_H3N2_MOI5_infected_6h	up	2.37	3.42e-46	RNA-Seq data
GSE71766	BEAS-2B_control_36hrs	BEAS-2B_InfluenzaVirus_36hrs	up	3.34	3.67e-15	Microarray data
GSE71766	BEAS-2B_control_36hrs	BEAS-2B_RhinoVirus_36hrs	up	2.48	2.83e-13	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_48hrs	up	3.23	5.03e-13	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_InfluenzaVirus_48hrs	up	3.05	3.08e-13	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_RhinoVirus_48hrs	up	3.00	1.81e-13	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	3.63	1.16e-133	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	2.98	6.35e-44	RNA-Seq data
GSE71766	BEAS-2B_control_60hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_60hrs	up	2.49	4.49e-14	Microarray data
GSE71766	BEAS-2B_control_60hrs	BEAS-2B_InfluenzaVirus_60hrs	up	2.23	1.59e-12	Microarray data
GSE71766	BEAS-2B_control_60hrs	BEAS-2B_RhinoVirus_60hrs	up	2.71	4.13e-13	Microarray data
GSE71766	BEAS-2B_control_72hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_72hrs	up	1.96	9.46e-11	Microarray data
GSE71766	BEAS-2B_control_72hrs	BEAS-2B_InfluenzaVirus_72hrs	up	1.82	9.78e-12	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	1.73	7.06e-56	RNA-Seq data
GSE71766	BEAS-2B_control_72hrs	BEAS-2B_RhinoVirus_72hrs	up	2.00	7.34e-12	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	up	4.04	6.08e-71	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	4.30	4.85e-84	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_24hrs	up	2.81	1.25e-14	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_36hrs	up	3.09	9.68e-16	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_48hrs	up	3.08	4.41e-15	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_60hrs	up	2.85	4.79e-16	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_72hrs	up	2.92	1.86e-14	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_24hrs	up	2.94	1.01e-15	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_03h	MDM-418_H3N2_MOI2_03h	up	1.59	6.87e-18	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_36hrs	up	3.03	9.72e-16	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_48hrs	up	2.90	9.04e-16	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	1.51	5.96e-26	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_60hrs	up	2.58	1.06e-14	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_72hrs	up	2.78	7.74e-16	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_36hrs	up	2.17	2.25e-13	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_48hrs	up	2.85	4.71e-16	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_60hrs	up	3.07	2.72e-15	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_72hrs	up	2.96	1.82e-15	Microarray data
GSE8961	Mock_infection	HMPV_infection_12h	up	1.93	4.29e-04	Microarray data
GSE8961	Mock_infection	HMPV_infection_24h	up	2.72	1.56e-05	Microarray data
GSE8961	Mock_infection	HMPV_infection_48h	up	2.57	4.67e-03	Microarray data
GSE8961	Mock_infection	HMPV_infection_72h	up	1.74	2.68e-05	Microarray data
GSE9378	HUVECs_mock-infected_control	HUVECs_DV_infection_48h	up	2.34	2.42e-02	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_12h	up	1.67	2.85e-02	Microarray data
GSE99858	PBMC_control	PBMC_RV16_infection	up	2.32	1.70e-08	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000115415
Gene description:	Signal transducer and activator of transcription 1
Chromosome:	2
Position	190964358-191020960
Protein class:	Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm, Cytosol