P40763 (STAT3)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: STAT3_HUMAN

UniProtID: P40763

Gene name(s): STAT3;APRF

Protein name: Signal transducer and activator of transcription 3

Gene ID: 6774

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P40763-P27958biogrid,HPIDB18985028two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: yes (score 0.103). Show
Machine learning evidence: yes (score 0.254).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1519IL6ST-PRKCD-STAT3 complex30.33 (1/3)12361954CORUMView
1520STAT3-NLK-MAP3K7 complex30.33 (1/3)15764709CORUMView
1521p300-SMAD1-STAT3 complex30.67 (2/3)10205054CORUMView
1522STAT3 homodimer complex11.00 (1/1)15653507CORUMView
298VEGF transcriptional complex40.25 (1/4)15735682CORUMView
7316NFKB1-STAT3 complex20.50 (1/2)12057007CORUMView
7317RELA-STAT3 complex20.50 (1/2)12057007CORUMView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE27702control_macrophagesFPV-infected_macrophagesdown-1.626.20e-03Microarray data
GSE32155CRL-5800_unifectedCRL-5807_infecteddown-1.552.83e-04Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-1.611.11e-04Microarray data
GSE89008HTBE_H5N1_MOI0_mock_infected_12hHTBE_H5N1_MOI5_infected_12hdown-1.664.13e-16RNA-Seq data
GSE89008HTBE_H5N1_MOI0_mock_infected_18hHTBE_H5N1_MOI5_infected_18hdown-1.999.93e-31RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 71.9 Liver: 53.0 Gallbladder: 127.5 Duodenum: 50.5 Rectum: 56.5 Tonsil: 64.3 Stomach: 45.6 Salivary glanda: 19.3 Adipose tissue: 125.4 Lung: 126.5 Lymph node: 71.8 Pancreas: 14.2 Kidney: 59.4 Colon: 54.3 Appendix: 118.3 Smooth musle: 111.1 Breast: 72.6 Parathyroid gland: 68.6 Esophagus: 90.5 Heart muscle: 36.1 Spleen: 98.5 Skeletal muscle: 30.3 Bone marrow: 62.2 Skin: 65.9 Urinary bladder: 78.2 Cervix, uterine: 78.9 Endometrium: 84.1 Ovary: 46.3 Fallopian tube: 92.0 Seminal vesicle: 71.8 Prostate: 103.1 Epididymis: 38.7 Testis: 51.1 Placenta: 86.3 Thyroid gland: 83.0 Cerebral cortex: 57.3 Adrenal gland: 73.3
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000168610
Gene description:Signal transducer and activator of transcription 3
Chromosome:17
Position42313324-42388568
Protein class:Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Cytosol