P38936 (CDKN1A)
Homo sapiensP27958-PRO_0000037566 (NA)
Hepatitis C virus genotype 1a (isolate H) (HCV)Human protein: CDN1A_HUMAN
UniProtID: P38936
Gene name(s): CDKN1A;CAP20;CDKN1;CIP1;MDA6;PIC1;SDI1;WAF1
Protein name: Cyclin-dependent kinase inhibitor 1
Gene ID: 1026
HDF/HRF: NA
Virus protein: Core protein p21(POLG_HCVH) (HCV-H)
UniProtID: P27958-PRO_0000037566
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| P38936-P27958-PRO_0000037566 | HPIDB | 10873631 | pull down |
| Interolog evidence: | yes (score 0.631). | Show |
| DDI evidence: | none/insignificant. | |
| Machine learning evidence: | yes (score 0.809). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 1634 | CyclinD1-CDK4-p21 complex | 3 | 0.33 (1/3) | 9467962 | CORUM | View |
| 310 | Cell cycle kinase complex CDC2 | 6 | 0.17 (1/6) | 7903056 | CORUM | View |
| 311 | Cell cycle kinase complex CDK2 | 4 | 0.25 (1/4) | 7903056 | CORUM | View |
| 312 | Cell cycle kinase complex CDK4 | 4 | 0.25 (1/4) | 7903056 | CORUM | View |
| 313 | Cell cycle kinase complex CDK5 | 5 | 0.20 (1/5) | 7903056 | CORUM | View |
| 314 | PCNA-p21 complex | 2 | 0.50 (1/2) | 8861913 | CORUM | View |
| 5101 | CyclinD3-CDK4-CDK6-p21 complex | 4 | 0.25 (1/4) | 8930396 | CORUM | View |
| 5622 | HSP90-CIP1-FKBPL complex | 3 | 0.67 (2/3) | 15664193 | CORUM | View |
| 6300 | CDKN1A-TP53-CDK1-PCNA complex | 3 | 0.67 (2/3) | 7624128 | CORUM | View |
| 893 | Cell cycle kinase complex CDK2 | 3 | 0.33 (1/3) | NA | hu.MAP | View |
| 2412 | p27-cyclinE-CDK2 complex | 7 | 0.14 (1/7) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE83525 | B19_NS1_unexpressed | B19_NS1_expressed | up | 1.61 | 1.74e-37 | RNA-Seq data |
| GSE72925 | Normal | PVAN | up | 1.52 | 6.25e-06 | Microarray data |
| GSE28166 | mock_infected_24h | VN1203_infected_24h | up | 2.25 | 2.29e-04 | Microarray data |
| GSE32140-GPL6947 | mock_for_influenza_2h | influenza_infection_2h | up | 2.29 | 5.11e-03 | Microarray data |
| GSE32155 | CRL-5810_unifected | CRL-1472_infected | up | 2.07 | 1.99e-02 | Microarray data |
| GSE32155 | CRL-5810_unifected | CRL-5807_infected | up | 1.94 | 2.85e-02 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_Anhui01_pCalu3_24h | up | 3.97 | 4.06e-06 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_Pan99_pCalu3_24h | up | 3.24 | 5.37e-05 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_VN1203_pCalu3_24h | up | 2.66 | 2.93e-04 | Microarray data |
| GSE85493 | MeWo_uninfected_36h | MeWo_Y881-920F_infected_36h | up | 1.59 | 1.24e-02 | RNA-Seq data |
| GSE99298 | mock_infected_0h | hRSV_WT_infected_96h | up | 4.25 | 6.87e-10 | RNA-Seq data |
| GSE99389 | CD4+_mock_infected_1d | LPS_infected_1d | up | 1.62 | 8.01e-04 | RNA-Seq data |
| GSE99298 | mock_infected_0h | hRSV_NS1_Y125A_infected_96h | up | 7.25 | 7.84e-27 | RNA-Seq data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000124762 |
| Gene description: | Cyclin dependent kinase inhibitor 1A |
| Chromosome: | 6 |
| Position | 36676460-36687339 |
| Protein class: | Cancer-related genes, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleoplasm, Nuclear bodies |