HVIDB-PPI detail

P37231 (PPARG)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: PPARG_HUMAN

UniProtID: P37231

Gene name(s): PPARG;NR1C3

Protein name: Peroxisome proliferator-activated receptor gamma

Gene ID: 5468

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P37231-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.930).	Show
DDI evidence:	yes (score 0.025).	Show
Machine learning evidence:	yes (score 0.691).

Combined Score: 1.000

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE24238	Mock_24h	HCMV_24h	down	-2.53	2.42e-02	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-1.73	1.93e-05	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	down	-2.12	2.26e-03	Microarray data
GSE30723	AMs_control_4h	AMs_PR8_4h	down	-1.64	3.70e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	6.10	6.29e-06	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	5.36	1.48e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	10.64	3.24e-07	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	9.90	4.74e-07	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	up	1.54	1.63e-04	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	2.28	1.30e-02	Microarray data
GSE53543	uninfected_control	RV_infected	down	-1.72	3.28e-39	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.20	1.37e-04	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	2.26	5.94e-05	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	1.85	1.97e-02	Microarray data
GSE99389	CD4+_mock_infected_1d	LPS_infected_1d	down	-3.51	5.88e-12	RNA-Seq data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-1.55	1.35e-03	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	down	-1.51	1.71e-02	Microarray data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-1.54	8.51e-21	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-2.63	3.16e-39	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-2.60	2.27e-28	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.38	1.03e-46	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-2.30	3.50e-53	RNA-Seq data
GSE83259	NIKS_control	NIKS_HPV18	up	2.08	5.72e-04	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
adipose tissue	173.3

Ensembl ID:	ENSG00000132170
Gene description:	Peroxisome proliferator activated receptor gamma
Chromosome:	3
Position	12287368-12434356
Protein class:	Cancer-related genes, Disease related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors
Evidence:	Evidence at protein level
Subcellular location:	Nucleus, Vesicles