HVIDB-PPI detail

P31629 (HIVEP2)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: ZEP2_HUMAN

UniProtID: P31629

Gene name(s): HIVEP2

Protein name: Transcription factor HIVEP2

Gene ID: 3097

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P31629-P27958	biogrid,HPIDB	18985028	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.181).

Combined Score: 0.199

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	up	2.60	2.15e-26	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	up	2.10	1.51e-10	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	4.01	4.36e-02	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	2.09	7.86e-05	RNA-Seq data
GSE84188	mock_infected_2d	RESTV_infected_2d	up	1.72	1.71e-02	RNA-Seq data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	1.68	2.13e-04	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	1.67	9.47e-03	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	2.96	2.72e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	1.60	5.16e-04	Microarray data
GSE40711	mock_infected_6h	IDN3006_or_cl2PA_infected_6h	up	1.66	1.41e-04	Microarray data
GSE43794	NPCs_jCV_infection_0h	NPCs_jCV_infection_30d	up	1.72	1.77e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.71	2.86e-05	Microarray data
GSE97949	uninfected_0h	H7N9_infected_7h	down	-2.22	3.38e-67	RNA-Seq data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	up	1.57	4.13e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	1.84	1.05e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	up	3.51	2.81e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	up	3.36	3.04e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	up	3.68	7.47e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	3.45	6.28e-03	Microarray data
GSE87750-GPL16791	hNCC_mock_infected	hNCC_ZIKV-PRVABC59_infected	up	1.57	2.46e-03	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	2.72	1.56e-62	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	2.12	1.02e-39	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	2.21	6.59e-18	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	1.84	4.33e-30	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	up	2.16	1.80e-04	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	2.08	1.40e-23	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	up	2.89	1.10e-44	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	3.70	3.39e-69	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	3.30	1.87e-72	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	3.35	9.10e-63	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	2.88	1.62e-66	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	3.60	1.84e-76	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_72h	up	1.86	2.62e-05	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_12h	up	2.54	1.06e-02	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	2.35	3.12e-03	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_6h	up	2.14	2.20e-02	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000010818
Gene description:	Human immunodeficiency virus type I enhancer binding protein 2
Chromosome:	6
Position	142751467-142956698
Protein class:	Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm