HVIDB-PPI detail

P29966 (MARCKS)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: MARCS_HUMAN

UniProtID: P29966

Gene name(s): MARCKS;MACS;PRKCSL

Protein name: Myristoylated alanine-rich C-kinase substrate

Gene ID: 4082

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P29966-P27958	PHISTO,biogrid,HPIDB,VirusMentha	22810585	affinity chromatography technology,tandem affinity purification

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	yes (score 0.065).	Show
Machine learning evidence:	yes (score 0.185).

Combined Score: 0.994

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-1.86	1.80e-15	RNA-Seq data
GSE24238	Mock_24h	HCMV_24h	up	3.14	2.35e-03	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-1.89	1.33e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-2.48	2.48e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-2.31	4.50e-05	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-1.82	2.17e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-2.13	8.74e-06	Microarray data
GSE47937	mock_infected	A_WSN_33_infected	down	-1.60	9.31e-07	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group1	down	-1.71	1.16e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-2.48	9.37e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-2.41	2.65e-07	Microarray data
GSE59226	Control	Virus_infection	down	-2.00	1.65e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	up	1.54	2.14e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	up	2.07	2.62e-04	Microarray data
GSE99389	CD4+_mock_infected_1d	LPS_infected_1d	up	1.74	4.27e-08	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.87	4.21e-39	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-3.14	2.14e-60	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	1.57	5.17e-15	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	1.62	2.04e-14	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	2.74	2.75e-19	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	2.73	2.22e-17	RNA-Seq data
GSE99858	PBMC_control	PBMC_RV16_infection	up	1.75	3.51e-09	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000277443
Gene description:	Myristoylated alanine rich protein kinase C substrate
Chromosome:	6
Position	113857362-113863471
Protein class:	Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleus, Endoplasmic reticulum, Plasma membrane, Cytosol