HVIDB-PPI detail

P29590 (PML)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: PML_HUMAN

UniProtID: P29590

Gene name(s): PML;MYL;PP8675;RNF71;TRIM19

Protein name: Protein PML

Gene ID: 5371

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P29590-P27958	PHISTO	16322229	anti bait coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.187).

Combined Score: 0.215

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1055	ZNF198-PML complex	2	0.50 (1/2)	17027752	CORUM	View
1827	PML-SMAD2/3-SARA complex	4	0.75 (3/4)	15356634	CORUM	View
490	ZNF198-PML complex	2	0.50 (1/2)	NA	hu.MAP	View
1995	ZNF198-PML complex	4	0.25 (1/4)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE101760	control_infected	PR8_NS1_infected	up	4.46	4.07e-13	RNA-Seq data
GSE101760	mock_infected	PR8_NS1_infected	up	4.37	1.95e-09	RNA-Seq data
GSE102481	mock_infected_9h	RVFV_MP12_infected_9h	up	1.89	6.73e-04	RNA-Seq data
GSE102924	control	ZIKV-Brazil_Dakar_strains	up	1.60	2.91e-05	RNA-Seq data
GSE61141	non-asthmatic_Vehicle	non-asthmatic_HRV16	up	2.74	2.36e-26	RNA-Seq data
GSE68673	A549_uninfected	A549_infected	up	1.86	4.98e-05	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	2.74	1.54e-18	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	2.29	4.68e-11	RNA-Seq data
GSE15810	hMSCs_mock-transduced	hMSCs_BV-transduced	up	2.10	2.89e-03	Microarray data
GSE24238	Mock_24h	HCMV_24h	up	1.94	6.63e-04	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-2.20	7.43e-05	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-3.02	2.49e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-3.18	3.04e-05	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	1.98	4.43e-04	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	2.20	1.36e-05	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	2.41	4.99e-06	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	1.51	2.84e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	1.78	1.25e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	2.79	1.57e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	1.85	3.28e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	2.86	4.21e-05	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-1.80	7.80e-05	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-2.72	4.45e-05	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.83	2.93e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	up	1.77	5.39e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	2.36	1.09e-07	Microarray data
GSE93385	K048_mock_infected	K048_ZIKV_infected	up	2.68	5.06e-29	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	1.75	2.52e-04	Microarray data
GSE99298	mock_infected_0h	hRSV_WT_infected_96h	up	1.59	2.48e-03	RNA-Seq data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	2.18	1.24e-28	RNA-Seq data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	up	1.76	9.09e-04	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	1.57	3.93e-04	Microarray data
GSE67059-GPL10558	HRV-_healthy_control	HRV+_asymptomatic	up	1.86	8.69e-04	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	up	2.31	2.59e-41	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_6h	HTBE_H3N2_MOI5_infected_6h	up	2.24	3.46e-34	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	1.59	4.29e-16	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	2.34	3.94e-24	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	1.81	3.08e-24	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	up	1.79	1.44e-08	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	1.89	7.19e-15	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	1.67	1.17e-28	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	2.77	1.07e-46	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_03h	MDM-418_H3N2_MOI2_03h	up	2.77	6.89e-33	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	1.91	5.41e-20	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_03h	MDM-513_H5N1_MOI2_03h	up	1.53	4.67e-09	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000140464
Gene description:	Promyelocytic leukemia
Chromosome:	15
Position	73994673-74047812
Protein class:	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nuclear bodies