P28070 (PSMB4)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: PSB4_HUMAN

UniProtID: P28070

Gene name(s): PSMB4;PROS26

Protein name: Proteasome subunit beta type-4

Gene ID: 5692

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P28070-P27958PHISTO14623081two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.140).
Combined Score: 0.111


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
18126S proteasome220.14 (3/22)11812135CORUMView
19120S proteasome140.14 (2/14)7811265CORUMView
192PA28-20S proteasome160.12 (2/16)11676531CORUMView
193PA700-20S-PA28 complex360.08 (3/36)11676531CORUMView
194PA28gamma-20S proteasome150.20 (3/15)7811265CORUMView
2959SMAD1-OAZ-HsN3 complex30.33 (1/3)12097147CORUMView
151220S proteasome130.15 (2/13)NAhu.MAPView
2511PA28-20S proteasome290.14 (4/29)NAhu.MAPView
3371PSMB4-AKIRIN220.50 (1/2)NAhu.MAPView
4639PSMB4-AKIRIN2-CEP120-CDK1840.25 (1/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_WT_15hpidown-1.586.34e-06Microarray data

Human tissue specific expression (TPM)

Small intestine: 149.2 Liver: 128.7 Gallbladder: 203.2 Duodenum: 144.3 Rectum: 175.0 Tonsil: 203.3 Stomach: 99.7 Salivary glanda: 72.5 Adipose tissue: 168.3 Lung: 177.0 Lymph node: 224.1 Pancreas: 28.6 Kidney: 183.7 Colon: 148.7 Appendix: 198.8 Smooth musle: 267.1 Breast: 201.7 Parathyroid gland: 210.1 Esophagus: 154.0 Heart muscle: 147.8 Spleen: 178.7 Skeletal muscle: 61.4 Bone marrow: 101.6 Skin: 183.4 Urinary bladder: 176.3 Cervix, uterine: 214.7 Endometrium: 207.9 Ovary: 209.1 Fallopian tube: 275.5 Seminal vesicle: 250.3 Prostate: 227.1 Epididymis: 258.2 Testis: 104.1 Placenta: 253.7 Thyroid gland: 244.1 Cerebral cortex: 177.0 Adrenal gland: 204.1
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000159377
Gene description:Proteasome subunit beta 4
Chromosome:1
Position151399534-151401944
Protein class:Enzymes, Plasma proteins, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Intermediate filaments, Centrosome, Cytosol