HVIDB-PPI detail

P28065 (PSMB9)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: PSB9_HUMAN

UniProtID: P28065

Gene name(s): PSMB9;LMP2;PSMB6i;RING12

Protein name: Proteasome subunit beta type-9

Gene ID: 5698

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P28065-P27958	biogrid,HPIDB	18985028	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.171).

Combined Score: 0.173

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
2511	PA28-20S proteasome	29	0.14 (4/29)	NA	hu.MAP	View
3100	PA28-20S proteasome	13	0.08 (1/13)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102924	control	ZIKV-Brazil_Dakar_strains	up	2.47	2.24e-03	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_24h	up	1.81	1.36e-02	RNA-Seq data
GSE72925	Normal	PVAN	up	2.34	3.09e-07	Microarray data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	1.79	1.05e-03	RNA-Seq data
GSE84285	A549_mock_infected_36h	A549_Dengue_virus_infected_36h	up	2.04	7.28e-07	RNA-Seq data
GSE13637	HUVEC_control	FPV-infected_HUVEC	up	1.90	5.85e-04	Microarray data
GSE13637	HUVEC_control	FPV-infected_IKK2kd-transfected_HUVEC	up	2.29	2.20e-04	Microarray data
GSE13637	HUVEC_control	FPV-infected_pEGZ-transfected_HUVEC	up	4.12	8.87e-08	Microarray data
GSE13637	HUVEC_control	H5N1-infected_HUVEC	up	2.84	5.04e-06	Microarray data
GSE13637	HUVEC_control	H5N1-infected_pEGZ-transfected_HUVEC	up	3.09	1.70e-06	Microarray data
GSE13637	HUVEC_control	PR8-infected_HUVEC	up	4.91	6.51e-08	Microarray data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	4.37	4.61e-06	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	5.53	1.11e-08	Microarray data
GSE14816	TB40E_mock	TB40E_TB	up	1.85	3.19e-03	Microarray data
GSE19345	Mock_infected	HCMV_infected_24h	down	-1.57	8.99e-05	Microarray data
GSE24238	Mock_24h	HCMV_24h	up	2.37	2.35e-03	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-1.56	1.33e-05	Microarray data
GSE30719	uninfected_primary_RPE	WNV_infected_primary_RPE_24h	up	3.27	9.33e-06	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	3.13	4.05e-04	Microarray data
GSE31193	control	IFN_6h	up	1.85	6.39e-07	Microarray data
GSE31193	control	IL2B_24h	up	2.61	3.03e-07	Microarray data
GSE31193	control	IL2B_6h	up	1.80	9.77e-06	Microarray data
GSE31524	H5N2-F118_Mock_infection	H5N2-F118_infection_10h	up	2.00	6.44e-06	Microarray data
GSE31524	H5N2-F118_Mock_infection	H5N2-F118_infection_8h	up	1.57	1.01e-05	Microarray data
GSE59226	Control	Inactivate	up	1.75	7.91e-05	Microarray data
GSE31524	H5N2-F189_Mock_infection	H5N2-F189_infection_10h	up	2.67	4.96e-07	Microarray data
GSE31524	H5N2-F59_Mock_infection	H5N2-F59_infection_10h	up	3.30	3.42e-07	Microarray data
GSE31524	H5N3_Mock_infection	H5N3_infection_10h	up	2.16	3.70e-06	Microarray data
GSE31524	H9N2_Mock_infection	H9N2_infection_10h	up	2.18	1.27e-07	Microarray data
GSE31524	H9N2_Mock_infection	H9N2_infection_8h	up	1.57	2.06e-04	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	2.53	6.47e-06	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	1.85	1.13e-04	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	2.46	3.74e-02	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	1.53	1.69e-02	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-2.75	6.10e-06	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-2.42	2.77e-04	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.78	1.67e-04	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	down	-2.93	1.02e-06	Microarray data
GSE48200	A549_Control_Mock	A549_NS1_M106I	up	1.70	3.89e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	up	2.27	4.36e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	up	2.23	6.66e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	4.09	4.41e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	2.14	9.93e-07	Microarray data
GSE53103	HeLa_no_infection	Hela_SV_12h	up	3.25	1.16e-07	Microarray data
GSE53103	Namalwa_shmH2A1	Namalwa_shmH2A1_+SV_6h	up	1.64	3.47e-02	Microarray data
GSE57647	Mock_infection_48h	JEV_infection_48h	up	1.56	8.94e-05	Microarray data
GSE93385	K048_mock_infected	K048_ZIKV_infected	up	2.22	3.38e-05	RNA-Seq data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-2.40	7.66e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-2.01	5.24e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.24	5.64e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-1.51	3.63e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-2.19	3.27e-03	Microarray data
GSE99298	mock_infected_0h	hRSV_WT_infected_96h	up	2.83	1.69e-06	RNA-Seq data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-2.03	1.93e-02	Microarray data
GSE65699	PRE_mock	PRE_infection_RKAA	up	2.00	7.06e-12	Microarray data
GSE65699	PRE_mock	PRE_infection_WT	up	2.01	1.34e-12	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	up	1.76	6.80e-04	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	1.71	1.39e-03	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	up	3.69	2.08e-16	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	4.10	3.41e-29	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	3.89	6.76e-06	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	1.72	1.16e-05	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	up	3.34	3.25e-13	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	4.30	7.79e-12	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	2.37	2.53e-18	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	2.92	2.41e-08	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	2.22	2.50e-03	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_12h	up	2.35	1.94e-04	Microarray data
GSE8961	Mock_infection	HMPV_infection_24h	up	3.78	1.92e-08	Microarray data
GSE8961	Mock_infection	HMPV_infection_48h	up	3.53	7.13e-04	Microarray data
GSE8961	Mock_infection	HMPV_infection_72h	up	2.63	4.08e-06	Microarray data
GSE9378	HUVECs_mock-infected_control	HUVECs_DV_infection_48h	up	4.59	2.12e-03	Microarray data
GSE93861	healthy_blood_control	Ebola_infection	up	1.60	1.32e-13	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_12h	up	1.54	1.36e-02	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	1.80	1.66e-03	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000240065
Gene description:	Proteasome subunit beta 9
Chromosome:	6
Position	32844136-32859585
Protein class:	Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Cytosol