HVIDB-PPI detail

P28062 (PSMB8)

Homo sapiens

P27958-PRO_0000037573 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: PSB8_HUMAN

UniProtID: P28062

Gene name(s): PSMB8;LMP7;PSMB5i;RING10;Y2

Protein name: Proteasome subunit beta type-8

Gene ID: 5696

HDF/HRF: NA

Virus protein: Serine protease NS3(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037573

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P28062-P27958-PRO_0000037573	HPIDB	15303969	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.748).	Show
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.677).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1639	PA700 complex	30	0.10 (3/30)	NA	hu.MAP	View
2511	PA28-20S proteasome	29	0.14 (4/29)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE75699	HNBE_control_0h	HNBE_infected_24h	up	2.44	1.43e-02	RNA-Seq data
GSE84285	A549_mock_infected_36h	A549_Dengue_virus_infected_36h	up	2.06	5.00e-03	RNA-Seq data
GSE13637	HUVEC_control	FPV-infected_IKK2kd-transfected_HUVEC	up	2.03	9.55e-06	Microarray data
GSE13637	HUVEC_control	FPV-infected_pEGZ-transfected_HUVEC	up	2.86	4.46e-08	Microarray data
GSE13637	HUVEC_control	H5N1-infected_HUVEC	up	2.49	8.84e-07	Microarray data
GSE13637	HUVEC_control	H5N1-infected_IKK2kd-transfected_HUVEC	up	1.67	9.42e-06	Microarray data
GSE13637	HUVEC_control	H5N1-infected_pEGZ-transfected_HUVEC	up	2.48	3.94e-07	Microarray data
GSE13637	HUVEC_control	PR8-infected_HUVEC	up	2.70	8.59e-06	Microarray data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	3.19	3.42e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	3.81	1.86e-08	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-2.75	1.60e-05	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-2.50	4.12e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_7hpi	Vero_E6_SARS-Cov_WT_7hpi	down	-1.55	4.83e-04	Microarray data
GSE30719	uninfected_primary_RPE	WNV_infected_primary_RPE_24h	up	1.78	3.83e-03	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	2.02	1.02e-03	Microarray data
GSE31193	control	IL2B_24h	up	1.94	3.61e-06	Microarray data
GSE31524	H1N1_Mock_infection_10h	H1N1_infection_10h	up	1.60	1.02e-05	Microarray data
GSE59226	Control	Inactivate	up	1.56	1.62e-04	Microarray data
GSE31524	H5N2-F189_Mock_infection	H5N2-F189_infection_10h	up	1.93	6.25e-07	Microarray data
GSE31524	H5N2-F59_Mock_infection	H5N2-F59_infection_10h	up	2.49	1.49e-07	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	1.52	1.48e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	1.55	3.08e-03	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	1.86	4.72e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	1.88	6.22e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	1.97	4.52e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	4.53	3.17e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	4.61	2.38e-05	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.58	4.03e-04	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	down	-2.61	8.18e-04	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	down	-2.22	6.03e-08	Microarray data
GSE49628	Bcells_Quiescent	Bcells_Activation	up	1.83	2.12e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	up	1.58	4.59e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	2.56	3.93e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	1.87	4.03e-06	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	2.38	3.00e-02	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-1.73	1.06e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-1.67	8.68e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-1.60	2.40e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-1.62	7.97e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	1.74	1.88e-03	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	1.78	1.38e-07	RNA-Seq data
GSE65699	PRE_mock	PRE_infection_WT	up	1.64	1.17e-11	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	up	1.88	2.84e-07	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	1.89	9.91e-08	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	1.91	3.93e-02	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	up	2.08	2.49e-06	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	2.81	8.85e-05	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	1.50	1.18e-04	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	1.95	1.86e-03	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	1.56	1.40e-02	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	1.78	1.60e-02	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_24h	up	2.23	2.01e-05	Microarray data
GSE8961	Mock_infection	HMPV_infection_48h	up	2.01	1.07e-02	Microarray data
GSE8961	Mock_infection	HMPV_infection_72h	up	1.71	5.76e-05	Microarray data
GSE9378	HUVECs_mock-infected_control	HUVECs_DV_infection_48h	up	2.00	1.88e-02	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000204264
Gene description:	Proteasome subunit beta 8
Chromosome:	6
Position	32840717-32844703
Protein class:	Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Vesicles, Cytokinetic bridge