HVIDB-PPI detail

P28062 (PSMB8)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

Networks viewer (Cytoscape.js) and color tagging feature require Firefox or Chrome browsers to work properly

Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: PSB8_HUMAN

UniProtID: P28062

Gene name(s): PSMB8;LMP7;PSMB5i;RING10;Y2

Protein name: Proteasome subunit beta type-8

Gene ID: 5696

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P28062-P27958	PHISTO,biogrid,HPIDB	15303969	anti tag coimmunoprecipitation,affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.250).

Combined Score: 0.436

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1639	PA700 complex	30	0.10 (3/30)	NA	hu.MAP	View
2511	PA28-20S proteasome	29	0.14 (4/29)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE75699	HNBE_control_0h	HNBE_infected_24h	up	2.44	1.43e-02	RNA-Seq data
GSE84285	A549_mock_infected_36h	A549_Dengue_virus_infected_36h	up	2.06	5.00e-03	RNA-Seq data
GSE13637	HUVEC_control	FPV-infected_IKK2kd-transfected_HUVEC	up	2.03	9.55e-06	Microarray data
GSE13637	HUVEC_control	FPV-infected_pEGZ-transfected_HUVEC	up	2.86	4.46e-08	Microarray data
GSE13637	HUVEC_control	H5N1-infected_HUVEC	up	2.49	8.84e-07	Microarray data
GSE13637	HUVEC_control	H5N1-infected_IKK2kd-transfected_HUVEC	up	1.67	9.42e-06	Microarray data
GSE13637	HUVEC_control	H5N1-infected_pEGZ-transfected_HUVEC	up	2.48	3.94e-07	Microarray data
GSE13637	HUVEC_control	PR8-infected_HUVEC	up	2.70	8.59e-06	Microarray data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	3.19	3.42e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	3.81	1.86e-08	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-2.75	1.60e-05	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-2.50	4.12e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_7hpi	Vero_E6_SARS-Cov_WT_7hpi	down	-1.55	4.83e-04	Microarray data
GSE30719	uninfected_primary_RPE	WNV_infected_primary_RPE_24h	up	1.78	3.83e-03	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	2.02	1.02e-03	Microarray data
GSE31193	control	IL2B_24h	up	1.94	3.61e-06	Microarray data
GSE31524	H1N1_Mock_infection_10h	H1N1_infection_10h	up	1.60	1.02e-05	Microarray data
GSE59226	Control	Inactivate	up	1.56	1.62e-04	Microarray data
GSE31524	H5N2-F189_Mock_infection	H5N2-F189_infection_10h	up	1.93	6.25e-07	Microarray data
GSE31524	H5N2-F59_Mock_infection	H5N2-F59_infection_10h	up	2.49	1.49e-07	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	1.52	1.48e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	1.55	3.08e-03	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	1.86	4.72e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	1.88	6.22e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	1.97	4.52e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	4.53	3.17e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	4.61	2.38e-05	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.58	4.03e-04	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	down	-2.61	8.18e-04	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	down	-2.22	6.03e-08	Microarray data
GSE49628	Bcells_Quiescent	Bcells_Activation	up	1.83	2.12e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	up	1.58	4.59e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	2.56	3.93e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	1.87	4.03e-06	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	2.38	3.00e-02	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-1.73	1.06e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-1.67	8.68e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-1.60	2.40e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-1.62	7.97e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	1.74	1.88e-03	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	1.78	1.38e-07	RNA-Seq data
GSE65699	PRE_mock	PRE_infection_WT	up	1.64	1.17e-11	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	up	1.88	2.84e-07	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	1.89	9.91e-08	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	1.91	3.93e-02	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	up	2.08	2.49e-06	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	2.81	8.85e-05	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	1.50	1.18e-04	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	1.95	1.86e-03	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	1.56	1.40e-02	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	1.78	1.60e-02	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_24h	up	2.23	2.01e-05	Microarray data
GSE8961	Mock_infection	HMPV_infection_48h	up	2.01	1.07e-02	Microarray data
GSE8961	Mock_infection	HMPV_infection_72h	up	1.71	5.76e-05	Microarray data
GSE9378	HUVECs_mock-infected_control	HUVECs_DV_infection_48h	up	2.00	1.88e-02	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000204264
Gene description:	Proteasome subunit beta 8
Chromosome:	6
Position	32840717-32844703
Protein class:	Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Vesicles, Cytokinetic bridge