Human protein: HMGB2_HUMAN
UniProtID: P26583
Gene name(s): HMGB2;HMG2
Protein name: High mobility group protein B2
Gene ID: 3148
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| P26583-P27958 | PHISTO | 23487458 | protein array |
| Interolog evidence: | none/insignificant. |
| DDI evidence: | none/insignificant. |
| Machine learning evidence: | yes (score 0.131). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 280 | HMGB1-HMGB2-HSC70-ERP60-GAPDH complex | 5 | 0.20 (1/5) | 12517784 | CORUM | View |
| 701 | HMGB1-HMGB2-HSC70-ERP60-GAPDH complex | 4 | 0.25 (1/4) | NA | hu.MAP | View |
| 780 | CART complex | 48 | 0.12 (6/48) | NA | hu.MAP | View |
| 3964 | HMGB1-HMGB2-HSC70-ERP60-GAPDH complex | 2 | 0.50 (1/2) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE24238 | Mock_24h | HCMV_24h | down | -1.88 | 3.09e-03 | Microarray data |
| GSE28166 | mock_infected_18h | VN1203_infected_18h | down | -1.89 | 1.08e-03 | Microarray data |
| GSE28166 | mock_infected_24h | VN1203_infected_24h | down | -2.04 | 2.70e-04 | Microarray data |
| GSE32140-GPL6480 | mock_for_RSV_2h | RSV_infection | down | -3.34 | 2.65e-06 | Microarray data |
| GSE32140-GPL6947 | mock_for_influenza_2h | influenza_infection_2h | down | -3.06 | 1.24e-02 | Microarray data |
| GSE92496 | control_vector | HPV16_E6-E7_vector | up | 2.05 | 1.16e-09 | RNA-Seq data |
| GSE65123 | healthy_seronegative_control | HCV_infected | down | -3.48 | 4.26e-02 | Microarray data |
| GSE65574 | MCL001_mock_24h | MCL001_RFP-MERS_24h | down | -2.46 | 7.67e-03 | Microarray data |
| GSE65699 | PRE_mock | PRE_infection_RKAA | down | -2.01 | 9.11e-11 | Microarray data |
| GSE89008 | HTBE_H5N1_MOI0_mock_infected_6h | HTBE_H5N1_MOI5_infected_6h | down | -1.54 | 4.71e-09 | RNA-Seq data |
| GSE980 | monocyte-derived_dendritic_cells_control | MV-infected_dendritic_cells_12h | down | -1.54 | 1.36e-02 | Microarray data |
| GSE980 | monocyte-derived_dendritic_cells_control | MV-infected_dendritic_cells_6h | down | -2.19 | 8.05e-03 | Microarray data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000164104 |
| Gene description: | High mobility group box 2 |
| Chromosome: | 4 |
| Position | 173331695-173335125 |
| Protein class: | Plasma proteins, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleus, Nucleoli |