HVIDB-PPI detail

P25789 (PSMA4)

Homo sapiens

P27958-PRO_0000037573 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: PSA4_HUMAN

UniProtID: P25789

Gene name(s): PSMA4;HC9;PSC9

Protein name: Proteasome subunit alpha type-4

Gene ID: 5685

HDF/HRF: NA

Virus protein: Serine protease NS3(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037573

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P25789-P27958-PRO_0000037573	HPIDB	15303969	anti bait coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.670).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
181	26S proteasome	22	0.14 (3/22)	11812135	CORUM	View
191	20S proteasome	14	0.14 (2/14)	7811265	CORUM	View
192	PA28-20S proteasome	16	0.12 (2/16)	11676531	CORUM	View
193	PA700-20S-PA28 complex	36	0.08 (3/36)	11676531	CORUM	View
194	PA28gamma-20S proteasome	15	0.20 (3/15)	7811265	CORUM	View
1512	20S proteasome	13	0.15 (2/13)	NA	hu.MAP	View
2511	PA28-20S proteasome	29	0.14 (4/29)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	down	-1.85	2.96e-09	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_24h	up	2.22	3.15e-53	RNA-Seq data
GSE24238	Mock_24h	HCMV_24h	up	2.18	3.59e-03	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-3.48	1.58e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-4.03	4.21e-07	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	down	-1.55	7.91e-04	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	2.08	1.56e-02	Microarray data
GSE59226	Control	Virus_infection	down	-1.55	3.21e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-4.15	5.41e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-2.64	3.28e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-3.52	4.38e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	1.84	2.37e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	up	2.56	8.87e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	2.94	2.59e-02	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-2.62	3.74e-02	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	1.59	1.65e-27	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	1.79	1.40e-18	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	1.84	1.20e-11	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	up	1.65	1.25e-02	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	2.00	1.86e-20	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	1.57	3.83e-10	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	1.92	1.60e-28	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	2.18	2.56e-49	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000041357
Gene description:	Proteasome subunit alpha 4
Chromosome:	15
Position	78540405-78552419
Protein class:	Enzymes, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleus, Vesicles, Cytosol