P23528 (CFL1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: COF1_HUMAN

UniProtID: P23528

Gene name(s): CFL1;CFL

Protein name: Cofilin-1

Gene ID: 1072

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P23528-P27958PHISTO15846844pull down

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.135).
Combined Score: 0.104


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2255Cofilin-actin-CAP1 complex30.33 (1/3)11950878CORUMView
383Cofilin-actin-CAP1 complex40.25 (1/4)NAhu.MAPView
780CART complex480.12 (6/48)NAhu.MAPView
976ARPC4-SIPA1-RAI14-MYO5C-PPP1R9B-ARHGAP21-FLII-CORO1C-SSH2-CFL2-MYO5B-ARHGAP11A-ZBTB20-CFL1-TWF1-WDR1-PLEKHG3-CORO2A180.06 (1/18)NAhu.MAPView
2296CFL1-CAP220.50 (1/2)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE45042ELC001_mock_infected_24hECL001_EMC_infected_24hdown-1.666.82e-05Microarray data
GSE65574MCL001_mock_0hMCL001_dNSP16-MERS_0hdown-2.814.54e-02Microarray data
GSE65574MCL001_mock_0hMCL001_RFP-MERS_0hdown-2.612.81e-02Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hdown-2.417.20e-03Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-3.071.12e-03Microarray data
GSE65574MCL001_mock_12hMCL001_dNSP16-MERS_12hdown-2.571.36e-02Microarray data
GSE65574MCL001_mock_12hMCL001_icMERS_12hdown-2.838.66e-03Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-2.951.82e-03Microarray data
GSE65574MCL001_mock_24hMCL001_d4B-MERS_24hdown-1.871.67e-03Microarray data
GSE65574MCL001_mock_24hMCL001_dNSP16-MERS_24hdown-2.982.90e-03Microarray data
GSE65574MCL001_mock_24hMCL001_icMERS_24hdown-3.315.10e-03Microarray data
GSE65574MCL001_mock_7hMCL001_icMERS_7hdown-1.582.78e-02Microarray data

Human tissue specific expression (TPM)

Small intestine: 1219.5 Liver: 175.5 Gallbladder: 627.1 Duodenum: 1156.6 Rectum: 1061.5 Tonsil: 970.0 Stomach: 589.8 Salivary glanda: 125.9 Adipose tissue: 621.9 Lung: 782.5 Lymph node: 1107.8 Pancreas: 49.9 Kidney: 329.2 Colon: 1111.9 Appendix: 1225.4 Smooth musle: 1170.6 Breast: 430.6 Parathyroid gland: 509.8 Esophagus: 559.2 Heart muscle: 234.7 Spleen: 827.7 Skeletal muscle: 67.1 Bone marrow: 816.9 Skin: 457.7 Urinary bladder: 636.4 Cervix, uterine: 566.8 Endometrium: 688.9 Ovary: 283.6 Fallopian tube: 587.1 Seminal vesicle: 642.0 Prostate: 592.4 Epididymis: 400.3 Testis: 363.6 Placenta: 677.1 Thyroid gland: 460.8 Cerebral cortex: 1075.5 Adrenal gland: 411.1
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000172757
Gene description:Cofilin 1
Chromosome:11
Position65823022-65862026
Protein class:Plasma proteins, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location: