HVIDB-PPI detail

P22736 (NR4A1)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: NR4A1_HUMAN

UniProtID: P22736

Gene name(s): NR4A1;GFRP1;HMR;NAK1

Protein name: Nuclear receptor subfamily 4 group A member 1

Gene ID: 3164

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P22736-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.975).	Show
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.921).

Combined Score: 1.000

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE100839	mock_infected	EBOV_infected	up	1.54	4.01e-04	RNA-Seq data
GSE101760	control_infected	PR8_NS1_infected	up	2.15	1.18e-02	RNA-Seq data
GSE101760	mock_infected	PR8_NS1_infected	up	2.26	5.63e-03	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-5.50	1.35e-02	RNA-Seq data
GSE64677	mock_infected_72h	WT_infected_72h	up	2.11	5.34e-05	RNA-Seq data
GSE64677	mock_infected_96h	m15_virus_infected_96h	up	1.84	1.68e-07	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	4.00	8.35e-06	RNA-Seq data
GSE84897	MKN7_WT_control	MKN7_EBV_infected	down	-2.89	7.39e-04	RNA-Seq data
GSE28166	mock_infected_18h	VN1203_infected_18h	up	1.59	1.18e-03	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	2.22	1.64e-04	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	1.87	2.42e-05	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	down	-1.77	3.41e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.83	3.37e-03	Microarray data
GSE65574	MCL001_mock_0h	MCL001_d4B-MERS_0h	up	1.50	3.82e-02	Microarray data
GSE97949	uninfected_0h	H7N9_infected_7h	down	-3.25	8.68e-40	RNA-Seq data
GSE97949	uninfected_0h	H7N9_infected_3h	down	-2.96	4.90e-32	RNA-Seq data
GSE87750-GPL16791	hPN_mock_infected	hPN_ZIKV-PRVABC59_infected	up	2.52	2.27e-11	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	up	5.03	9.44e-19	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_2hrs	up	2.81	1.41e-14	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	6.23	1.34e-36	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_4hrs	up	1.64	7.91e-12	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	7.35	2.14e-03	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_2hrs	up	2.89	1.57e-14	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_4hrs	up	1.61	1.65e-11	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	9.39	1.19e-07	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_2hrs	up	2.61	1.05e-13	Microarray data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	5.43	3.60e-16	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	11.02	3.49e-11	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	5.60	4.97e-11	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	5.63	1.25e-06	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000123358
Gene description:	Nuclear receptor subfamily 4 group A member 1
Chromosome:	12
Position	52022832-52059507
Protein class:	Nuclear receptors, Predicted intracellular proteins, Transcription factors
Evidence:	Evidence at protein level
Subcellular location:	Nucleus, Cytosol