P21912 (SDHB)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: SDHB_HUMAN

UniProtID: P21912

Gene name(s): SDHB;SDH;SDH1

Protein name: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit

Gene ID: 6390

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P21912-P27958biogrid,HPIDB26845356two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.206).
Combined Score: 0.272


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
134SDHAF2-PDHA2-SDHB-SDHA40.25 (1/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE69602cytosol_unifectedcytosol_DENV2_infected_24hup7.217.77e-03RNA-Seq data
GSE65574MCL001_mock_0hMCL001_RFP-MERS_0hdown-2.232.10e-02Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hdown-2.414.00e-03Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-3.593.13e-04Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-2.871.21e-02Microarray data
GSE65574MCL001_mock_7hMCL001_RFP-MERS_7hdown-2.692.87e-02Microarray data

Human tissue specific expression (TPM)

Small intestine: 116.2 Liver: 158.9 Gallbladder: 65.8 Duodenum: 140.1 Rectum: 136.6 Tonsil: 69.4 Stomach: 71.1 Salivary glanda: 27.7 Adipose tissue: 84.4 Lung: 77.4 Lymph node: 74.3 Pancreas: 14.3 Kidney: 215.2 Colon: 119.2 Appendix: 71.2 Smooth musle: 92.9 Breast: 81.1 Parathyroid gland: 123.7 Esophagus: 77.8 Heart muscle: 163.7 Spleen: 73.5 Skeletal muscle: 153.1 Bone marrow: 50.4 Skin: 47.2 Urinary bladder: 68.0 Cervix, uterine: 79.1 Endometrium: 71.0 Ovary: 47.3 Fallopian tube: 86.0 Seminal vesicle: 75.2 Prostate: 81.3 Epididymis: 73.0 Testis: 104.9 Placenta: 72.3 Thyroid gland: 95.8 Cerebral cortex: 68.3 Adrenal gland: 103.8
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000117118
Gene description:Succinate dehydrogenase complex iron sulfur subunit B
Chromosome:1
Position17018722-17054170
Protein class:Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Plasma membrane, Mitochondria