HVIDB-PPI detail

P20671 (H2AC7)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: H2A1D_HUMAN

UniProtID: P20671

Gene name(s): H2AC7;H2AFG;HIST1H2AD

Protein name: Histone H2A type 1-D

Gene ID: 3013

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P20671-P27958	biogrid,HPIDB	22810585	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 1.000).	Show
DDI evidence:	yes (score 0.081).	Show
Machine learning evidence:	yes (score 0.149).

Combined Score: 0.999

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE75699	HNBE_control_0h	HNBE_infected_24h	down	-3.29	1.80e-02	RNA-Seq data
GSE78711-GPL18573	NPC_mock_infected	NPC_Zika_infected	up	2.41	6.25e-03	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	3.11	4.91e-04	RNA-Seq data
GSE84188	mock_infected_2d	RESTV_infected_2d	up	4.35	2.03e-06	RNA-Seq data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	2.05	4.85e-03	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	1.81	9.62e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-2.29	3.80e-04	Microarray data
GSE36854	NK_uninfected	IHD-W_infected	up	4.17	4.46e-02	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	1.61	1.07e-03	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_24h	up	1.62	2.82e-06	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	up	2.17	6.24e-08	Microarray data
GSE53103	Namalwa_shscr	Namalwa_shscr_+SV_6h	down	-2.04	2.05e-06	Microarray data
GSE92496	control_vector	HPV16_E6-E7_vector	up	2.09	2.86e-04	RNA-Seq data
GSE93385	K048_mock_infected	K048_ZIKV_infected	down	-1.79	6.26e-18	RNA-Seq data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-2.67	1.19e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-1.68	1.08e-03	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	up	2.54	5.98e-53	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.42	1.29e-18	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.14	1.23e-08	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	down	-2.34	7.69e-17	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	down	-3.43	3.88e-24	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	1.86	2.37e-07	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	up	1.75	7.00e-03	RNA-Seq data
GSE93861	healthy_blood_control	Ebola_infection	up	2.10	1.26e-11	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
bone marrow	2.2
prostate	1.9

Ensembl ID:	ENSG00000196866
Gene description:	Histone cluster 1 H2A family member d
Chromosome:	6
Position	26198851-26199243
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location: