P20226 (TBP)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: TBP_HUMAN

UniProtID: P20226

Gene name(s): TBP;GTF2D1;TF2D;TFIID

Protein name: TATA-box-binding protein

Gene ID: 6908

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P20226-P27958biogrid,HPIDB12379483affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.281).
Combined Score: 0.562


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
103RNA polymerase II holoenzyme complex240.04 (1/24)9305922CORUMView
11145S-DNA-TFIIIA-TFIIIC2-TFIIIB subcomplex90.11 (1/9)12711686CORUMView
1257ALL-1 supercomplex280.07 (2/28)12453419CORUMView
1318Transcription initiation factor complex (TAF1, TAF5, TAF11, TAF12, TBP)50.20 (1/5)9045704CORUMView
1321Transcription initiation factor complex (TAF5, TAF6, TAF9, TAF11, TBP)50.20 (1/5)9045704CORUMView
155TFIID complex90.11 (1/9)9836642CORUMView
1749SMN-PolII-RHA complex100.10 (1/10)11149922CORUMView
2825BRCA1-RNA polymerase II complex260.04 (1/26)9159119CORUMView
3009TFIID complex90.11 (1/9)16895980CORUMView
3064RNA polymerase II complex, chromatin structure modifying160.12 (2/16)9710619CORUMView
463TFIID complex110.09 (1/11)9603525CORUMView
469TFIID-beta complex120.08 (1/12)10591645CORUMView
484TFIID complex110.09 (1/11)7729427CORUMView
485TFIID complex, B-cell specific120.08 (1/12)8858156CORUMView
492DA complex150.07 (1/15)2247058CORUMView
493DAB complex160.06 (1/16)2247058CORUMView
508TFIID complex100.10 (1/10)8663456CORUMView
509TFIID complex120.08 (1/12)8890175CORUMView
514TFIID-beta complex120.08 (1/12)15899866CORUMView
5727TBP-TAF complex40.25 (1/4)7801123CORUMView
5736Pre-initiation complex (PIC)30.33 (1/3)15502823CORUMView
721PU.1-TBP complex20.50 (1/2)14647463CORUMView
196TFIID complex30.33 (1/3)NAhu.MAPView
1982TFIID complex40.25 (1/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE27702control_macrophagesFPV-infected_macrophagesdown-1.754.88e-03Microarray data
GSE27702control_macrophagesH5N1-infected_macrophagesdown-1.585.87e-03Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-1.991.03e-04Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-1.532.90e-05Microarray data
GSE59226ControlVirus_infectiondown-1.782.28e-04Microarray data
GSE89008HTBE_H5N1_MOI0_mock_infected_18hHTBE_H5N1_MOI5_infected_18hdown-1.693.98e-03RNA-Seq data
GSE97672-GPL16791MDM-513_H5N1_MOI0_06hMDM-513_H5N1_MOI2_06hdown-2.501.32e-07RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_06hMDM-520_H5N1_MOI2_06hdown-1.562.01e-05RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 9.9 Liver: 3.4 Gallbladder: 12.2 Duodenum: 8.2 Rectum: 9.2 Tonsil: 10.8 Stomach: 8.3 Salivary glanda: 4.4 Adipose tissue: 9.2 Lung: 12.2 Lymph node: 15.4 Pancreas: 1.5 Kidney: 7.7 Colon: 7.8 Appendix: 12.7 Smooth musle: 13.6 Breast: 11.3 Parathyroid gland: 10.8 Esophagus: 8.6 Heart muscle: 5.5 Spleen: 13.9 Skeletal muscle: 3.0 Bone marrow: 9.7 Skin: 12.5 Urinary bladder: 9.4 Cervix, uterine: 9.9 Endometrium: 16.8 Ovary: 14.0 Fallopian tube: 15.4 Seminal vesicle: 10.3 Prostate: 11.6 Epididymis: 9.9 Testis: 61.8 Placenta: 15.0 Thyroid gland: 14.7 Cerebral cortex: 13.5 Adrenal gland: 9.2
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000112592
Gene description:TATA-box binding protein
Chromosome:6
Position170554302-170572870
Protein class:Disease related genes, Predicted intracellular proteins, Transcription factors
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm