HVIDB-PPI detail

P19525 (EIF2AK2)

Homo sapiens

P27958-PRO_0000037576 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: E2AK2_HUMAN

UniProtID: P19525

Gene name(s): EIF2AK2;PKR;PRKR

Protein name: Interferon-induced

Gene ID: 5610

HDF/HRF: NA

Virus protein: Non-structural protein 5A(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037576

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P19525-P27958-PRO_0000037576	HPIDB	9143277	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.631).	Show
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.698).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
3893	RECQL-HPCAL1-EIF2AK2-CYP1A1	4	0.25 (1/4)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE101760	control_infected	PR8_NS1_infected	up	1.83	5.24e-03	RNA-Seq data
GSE101760	mock_infected	PR8_NS1_infected	up	1.76	1.79e-03	RNA-Seq data
GSE61141	non-asthmatic_Vehicle	non-asthmatic_HRV16	up	2.27	3.52e-31	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_24h	up	1.93	1.31e-58	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	2.26	4.25e-09	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	2.02	2.39e-11	RNA-Seq data
GSE84346	uninfected_control	HCV_infected_high_ISG	up	1.51	3.25e-07	RNA-Seq data
GSE14816	TB40E_mock	TB40E_TB	up	1.54	1.82e-03	Microarray data
GSE15810	hMSCs_mock-transduced	hMSCs_BV-transduced	up	2.17	1.20e-03	Microarray data
GSE24238	Mock_24h	HCMV_24h	up	2.06	1.26e-02	Microarray data
GSE30719	uninfected_primary_RPE	WNV_infected_primary_RPE_24h	up	2.08	2.02e-05	Microarray data
GSE31524	H5N2-F189_Mock_infection	H5N2-F189_infection_10h	up	1.77	5.80e-07	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	2.28	3.41e-06	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	2.51	1.82e-03	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	1.77	9.91e-03	Microarray data
GSE38900-GPL10558	healthy_matched_control	RSV_LRTI_infection	up	1.99	1.44e-04	Microarray data
GSE38900-GPL6884	Dallas_healthy_matched_control	Dallas_influenza_A_infection	up	1.81	1.65e-10	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	up	1.73	1.08e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	1.99	7.64e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	up	2.03	5.01e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	2.07	4.66e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	2.11	2.35e-07	Microarray data
GSE53103	Namalwa_shmH2A1	Namalwa_shmH2A1_+SV_6h	up	2.54	4.58e-03	Microarray data
GSE53543	uninfected_control	RV_infected	up	2.46	2.61e-106	Microarray data
GSE54293	NCI-H1666_mock	NCI-H1666_infected	up	1.92	2.46e-04	Microarray data
GSE57647	Mock_infection_24h	JEV_infection_24h	up	1.75	6.57e-06	Microarray data
GSE93385	K054_mock_infected	K054_ZIKV_infected	up	1.59	1.52e-11	RNA-Seq data
GSE93385	K048_mock_infected	K048_ZIKV_infected	up	2.61	4.47e-58	RNA-Seq data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	3.76	7.93e-65	RNA-Seq data
GSE65699	PRE_mock	PRE_infection_RKAA	up	1.51	4.68e-08	Microarray data
GSE65699	PRE_mock	PRE_infection_WT	up	2.16	1.01e-09	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	up	3.21	3.17e-05	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	3.20	5.25e-05	Microarray data
GSE67059-GPL10558	HRV-_healthy_control	HRV+_asymptomatic	up	1.58	2.35e-03	Microarray data
GSE71766	BEAS-2B_control_24hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_24hrs	up	1.87	1.09e-11	Microarray data
GSE71766	BEAS-2B_control_24hrs	BEAS-2B_InfluenzaVirus_24hrs	up	1.94	1.70e-12	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	up	1.52	1.67e-17	RNA-Seq data
GSE71766	BEAS-2B_control_36hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_36hrs	up	1.90	3.73e-13	Microarray data
GSE89008	HTBE_H3N2_MOI0_mock_infected_6h	HTBE_H3N2_MOI5_infected_6h	up	1.59	9.49e-13	RNA-Seq data
GSE71766	BEAS-2B_control_36hrs	BEAS-2B_InfluenzaVirus_36hrs	up	1.96	2.92e-13	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_48hrs	up	1.91	6.25e-12	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_InfluenzaVirus_48hrs	up	1.94	6.32e-12	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_RhinoVirus_48hrs	up	1.75	8.73e-12	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	2.12	2.45e-34	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	1.56	1.64e-08	RNA-Seq data
GSE71766	BEAS-2B_control_60hrs	BEAS-2B_RhinoVirus_60hrs	up	1.53	4.57e-12	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	1.65	2.92e-36	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	up	3.08	7.08e-25	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	3.02	7.48e-33	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_24hrs	up	1.71	2.63e-12	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_36hrs	up	1.73	2.21e-13	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_48hrs	up	1.68	2.70e-13	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_24hrs	up	1.79	4.37e-13	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_03h	MDM-418_H3N2_MOI2_03h	up	1.84	2.78e-19	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_36hrs	up	1.78	1.05e-13	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_48hrs	up	1.70	1.69e-13	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_48hrs	up	1.51	3.60e-13	Microarray data
GSE8961	Mock_infection	HMPV_infection_12h	up	1.57	2.43e-03	Microarray data
GSE8961	Mock_infection	HMPV_infection_24h	up	1.65	1.77e-05	Microarray data
GSE9378	HUVECs_mock-infected_control	HUVECs_DV_infection_48h	up	2.26	1.11e-02	Microarray data
GSE9378	Monocyte_mock-infected_control	Monocyte_DV_infection_48h	up	2.25	4.28e-02	Microarray data
GSE99858	PBMC_control	PBMC_RV16_infection	up	3.50	3.30e-14	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000055332
Gene description:	Eukaryotic translation initiation factor 2 alpha kinase 2
Chromosome:	2
Position	37099210-37157065
Protein class:	Enzymes, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Cytosol