HVIDB-PPI detail

P19438 (TNFRSF1A)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: TNR1A_HUMAN

UniProtID: P19438

Gene name(s): TNFRSF1A;TNFAR;TNFR1

Protein name: Tumor necrosis factor receptor superfamily member 1A

Gene ID: 7132

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P19438-P27958	biogrid,HPIDB	11821416	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.005).	Show
Machine learning evidence:	yes (score 0.089).

Combined Score: 0.063

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
5531	Tumor necrosis factor receptor 1 signaling complex	4	0.50 (2/4)	8943045	CORUM	View
6344	TNF-R1-associated signaling complex	15	0.33 (5/15)	20005846	CORUM	View
6347	TNF-R1 signaling complex	5	0.40 (2/5)	8612133	CORUM	View
2634	TNF-R1 signaling complex	3	0.33 (1/3)	NA	hu.MAP	View
3962	TNF-R1 signaling complex	2	0.50 (1/2)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE27702	control_macrophages	FPV-infected_macrophages	down	-1.62	1.45e-02	Microarray data
GSE27702	control_macrophages	H5N1-infected_macrophages	down	-1.77	1.64e-02	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-1.60	1.07e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-2.92	3.74e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-2.57	2.07e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	2.55	1.58e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	2.33	3.52e-04	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	down	-3.30	3.65e-04	Microarray data
GSE47937	mock_infected	A_WSN_33_infected	down	-2.76	2.35e-10	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group1	down	-2.75	4.90e-09	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group2	down	-2.83	1.91e-08	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	down	-1.84	1.38e-07	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	up	2.07	1.27e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-4.44	8.14e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-3.74	2.92e-07	Microarray data
GSE59226	Control	Virus_infection	down	-2.74	6.21e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-1.70	5.37e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.44	9.72e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-1.72	1.43e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-1.83	1.35e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	down	-1.79	2.19e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-2.50	8.43e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-2.43	2.76e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-2.99	9.15e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-2.71	8.66e-03	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-1.86	1.19e-15	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.04	3.76e-15	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-1.62	4.92e-02	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-1.66	6.88e-18	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-2.91	2.37e-42	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-3.18	3.72e-37	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-3.13	2.49e-39	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-3.08	5.72e-41	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000067182
Gene description:	TNF receptor superfamily member 1A
Chromosome:	12
Position	6328757-6342114
Protein class:	Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Evidence:	Evidence at protein level
Subcellular location: