Human protein: NUCL_HUMAN
UniProtID: P19338
Gene name(s): NCL
Protein name: Nucleolin
Gene ID: 4691
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| P19338-P27958 | PHISTO | 12427757 | pull down |
| Interolog evidence: | none/insignificant. |
| DDI evidence: | none/insignificant. |
| Machine learning evidence: | yes (score 0.239). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 1191 | RNA pol II containing coactivator complex Tat-SF | 5 | 0.20 (1/5) | 10393184 | CORUM | View |
| 1729 | TLE1 corepressor complex (MASH1 promoter-corepressor complex) | 10 | 0.20 (2/10) | 15607978 | CORUM | View |
| 2599 | POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex | 6 | 0.17 (1/6) | 10983978 | CORUM | View |
| 3055 | Nop56p-associated pre-rRNA complex | 104 | 0.12 (12/104) | 12777385 | CORUM | View |
| 3078 | DGCR8-NCL complex | 2 | 0.50 (1/2) | 17765891 | CORUM | View |
| 3082 | DGCR8 multiprotein complex | 11 | 0.36 (4/11) | 17765891 | CORUM | View |
| 3135 | TLE1 corepressor complex (MASH1 promoter-corepressor complex) | 8 | 0.25 (2/8) | 15607978 | CORUM | View |
| 92 | CD28-transactivation complex | 2 | 0.50 (1/2) | 12324461 | CORUM | View |
| 427 | RNA polymerase II (RNAPII) | 7 | 0.14 (1/7) | NA | hu.MAP | View |
| 2146 | Ribosome, cytoplasmic | 143 | 0.13 (18/143) | NA | hu.MAP | View |
| 2985 | Ribosome, cytoplasmic | 139 | 0.12 (16/139) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE59226 | Control | Virus_infection | up | 1.51 | 4.12e-04 | Microarray data |
| GSE65574 | MCL001_mock_12h | MCL001_d4B-MERS_12h | down | -2.13 | 3.41e-05 | Microarray data |
| GSE65574 | MCL001_mock_12h | MCL001_RFP-MERS_12h | down | -1.57 | 3.97e-03 | Microarray data |
| GSE99298 | mock_infected_0h | hRSV_WT_infected_96h | down | -1.62 | 2.24e-03 | RNA-Seq data |
| GSE65574 | MCL001_mock_24h | MCL001_icMERS_24h | down | -2.12 | 6.65e-03 | Microarray data |
| GSE65574 | MCL001_mock_7h | MCL001_RFP-MERS_7h | down | -1.66 | 1.07e-03 | Microarray data |
| GSE99298 | mock_infected_0h | hRSV_NS1_Y125A_infected_96h | down | -1.59 | 1.16e-04 | RNA-Seq data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000115053 |
| Gene description: | Nucleolin |
| Chromosome: | 2 |
| Position | 231453531-231483641 |
| Protein class: | Plasma proteins, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleus, Nucleoli |