P18850 (ATF6)

Homo sapiens

P27958-PRO_0000037575 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: ATF6A_HUMAN

UniProtID: P18850

Gene name(s): ATF6

Protein name: Cyclic AMP-dependent transcription factor ATF-6 alpha

Gene ID: 22926

HDF/HRF: NA

Virus protein: Non-structural protein 4B(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037575

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P18850-P27958-PRO_0000037575HPIDB12445808two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.640).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1481TMEM131-TTC17-ATF630.33 (1/3)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE28166mock_infected_18hVN1203_infected_18hdown-2.221.32e-02Microarray data
GSE28166mock_infected_24hVN1203_infected_24hdown-1.994.97e-03Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infectedup1.736.56e-05Microarray data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-1.642.80e-24RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-1.741.98e-32RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 10.3 Liver: 11.5 Gallbladder: 16.2 Duodenum: 8.7 Rectum: 14.3 Tonsil: 10.5 Stomach: 10.7 Salivary glanda: 4.6 Adipose tissue: 15.5 Lung: 18.5 Lymph node: 11.8 Pancreas: 5.7 Kidney: 17.4 Colon: 10.5 Appendix: 17.3 Smooth musle: 20.1 Breast: 17.1 Parathyroid gland: 41.3 Esophagus: 12.0 Heart muscle: 5.6 Spleen: 14.9 Skeletal muscle: 2.1 Bone marrow: 5.4 Skin: 12.6 Urinary bladder: 12.9 Cervix, uterine: 16.0 Endometrium: 19.4 Ovary: 11.4 Fallopian tube: 16.0 Seminal vesicle: 17.8 Prostate: 18.6 Epididymis: 23.3 Testis: 17.4 Placenta: 26.5 Thyroid gland: 26.7 Cerebral cortex: 19.9 Adrenal gland: 12.5
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000118217
Gene description:Activating transcription factor 6
Chromosome:1
Position161766294-161964070
Protein class:Disease related genes, Plasma proteins, Predicted membrane proteins, Transcription factors
Evidence:Evidence at protein level
Subcellular location:Cytosol