HVIDB-PPI detail

P15144 (ANPEP)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: AMPN_HUMAN

UniProtID: P15144

Gene name(s): ANPEP;APN;CD13;PEPN

Protein name: Aminopeptidase N

Gene ID: 290

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P15144-P27958	biogrid,HPIDB	26845356	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.065).

Combined Score: 0.035

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	up	5.52	1.20e-02	RNA-Seq data
GSE68673	A549_uninfected	A549_infected	down	-1.95	2.42e-02	RNA-Seq data
GSE79968	IMR90_GFP_48h	IMR90_MCPyV_ST_48h	down	-1.68	8.28e-64	RNA-Seq data
GSE1377	uninfected_control	KSHV_infected	down	-2.62	4.50e-02	Microarray data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-3.40	8.92e-03	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-4.04	1.04e-04	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	down	-2.59	3.01e-02	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-3.08	2.20e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	down	-3.26	4.44e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-1.65	5.88e-03	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	down	-1.83	7.35e-03	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-3.77	7.23e-04	Microarray data
GSE40711	mock_infected_6h	IDN3006_or_cl2PA_infected_6h	down	-1.52	1.08e-04	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-5.79	2.01e-04	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	down	-1.74	7.48e-07	Microarray data
GSE67059-GPL10558	HRV-_healthy_control	HRV+_asymptomatic	up	1.52	7.15e-03	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.08	1.17e-10	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.68	2.66e-11	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-1.85	1.85e-24	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-2.72	8.06e-07	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-2.06	1.33e-29	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-1.51	3.50e-21	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_72hrs	down	-1.58	1.12e-10	Microarray data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-3.09	8.94e-47	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-3.47	1.33e-61	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-3.62	1.64e-75	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-2.16	1.44e-32	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Group enriched:

Tissue	Expression (TPM)
duodenum	2386.4
small intestine	2133.7

Ensembl ID:	ENSG00000166825
Gene description:	Alanyl aminopeptidase, membrane
Chromosome:	15
Position	89784889-89815401
Protein class:	CD markers, Enzymes, Plasma proteins, Predicted membrane proteins
Evidence:	Evidence at protein level
Subcellular location:	Plasma membrane