HVIDB-PPI detail

P14373 (TRIM27)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: TRI27_HUMAN

UniProtID: P14373

Gene name(s): TRIM27;RFP;RNF76

Protein name: Zinc finger protein RFP

Gene ID: 5987

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P14373-P27958	biogrid,HPIDB	18985028	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.235).

Combined Score: 0.375

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
5663	TRIM27-RB1 complex	2	0.50 (1/2)	15837424	CORUM	View
6136	USP7-MAGEL2-TRIM27 complex	3	0.33 (1/3)	26365382	CORUM	View
241	USP7-MAGEL2-TRIM27 complex	4	0.25 (1/4)	NA	hu.MAP	View
579	USP7-MAGEL2-TRIM27 complex	4	0.25 (1/4)	NA	hu.MAP	View
1265	TRIM27-RB1 complex	2	0.50 (1/2)	NA	hu.MAP	View
1304	TRIM27-RB1 complex	2	0.50 (1/2)	NA	hu.MAP	View
1873	USP7-MAGEL2-TRIM27 complex	8	0.12 (1/8)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	down	-2.33	2.26e-02	RNA-Seq data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-1.73	2.08e-03	Microarray data
GSE27702	control_macrophages	H5N1-infected_macrophages	down	-2.23	1.74e-03	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-2.68	6.62e-05	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-3.03	1.72e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-2.74	8.40e-05	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-1.60	9.25e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-1.56	4.76e-05	Microarray data
GSE30723	AMs_control_4h	AMs_PR8_4h	down	-1.51	4.08e-03	Microarray data
GSE40711	mock_infected_6h	IDN3006_or_cl2PA_infected_6h	down	-1.59	1.01e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-2.10	3.03e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-3.08	6.19e-08	Microarray data
GSE59226	Control	Virus_infection	down	-2.09	1.45e-04	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_6h	HTBE_H5N1_MOI5_infected_6h	down	-1.96	1.13e-04	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-3.07	1.09e-07	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.07	2.39e-02	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-1.87	2.66e-03	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-2.58	3.31e-04	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-2.07	1.01e-04	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-3.42	1.60e-06	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.07	1.15e-02	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-2.86	1.78e-03	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000204713
Gene description:	Tripartite motif containing 27
Chromosome:	6
Position	28903002-28923989
Protein class:	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleus, Nucleoli