HVIDB-PPI detail

Homo sapiens

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Human protein: SRC_HUMAN

UniProtID: P12931

Gene name(s): SRC;SRC1

Protein name: Proto-oncogene tyrosine-protein kinase Src

Gene ID: 6714

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P12931-P27958	biogrid,HPIDB	16139795	affinity chromatography technology

Evidence suggesting a protein interaction:

Combined Score: 0.998

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
2073	TNFRSF11A-TRAF6-SRC complex	3	0.33 (1/3)	10635328	CORUM	View
2377	ITGA2b-ITGB3-CD47-SRC complex	4	0.25 (1/4)	9169439	CORUM	View
2470	p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex	4	0.25 (1/4)	15020686	CORUM	View
2471	SRC-PRKCD-CDCP1 complex	3	0.33 (1/3)	15851033	CORUM	View
3137	MASH1 promoter-coactivator complex	9	0.33 (3/9)	15607978	CORUM	View
3142	CAMK2-delta-MASH1 promoter-coactivator complex	8	0.25 (2/8)	15607978	CORUM	View
5177	Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)	11	0.18 (2/11)	11113628	CORUM	View
5282	CAS-SRC-FAK complex	3	0.33 (1/3)	9148935	CORUM	View
5713	SH3P2/OSTF1-CBL-SRC complex	3	0.33 (1/3)	15135048	CORUM	View
5928	CNK1-SRC-RAF1 complex	3	0.33 (1/3)	15845549	CORUM	View
6176	CDCP1-Src-EGFR complex	3	0.33 (1/3)	27495374	CORUM	View
7248	ABCB1-ANXA2-RACK1-SRC complex	4	0.50 (2/4)	27754360	CORUM	View
270	SRC-EEPD1	2	0.50 (1/2)	NA	hu.MAP	View
2555	SRC-EEPD1-CPNE8-TLDC1-EFR3A	5	0.20 (1/5)	NA	hu.MAP	View
3771	PALM-SRC-CCNY	3	0.33 (1/3)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-2.14	1.87e-06	RNA-Seq data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-1.56	1.54e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-2.82	4.26e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-2.88	1.69e-06	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	up	2.72	1.60e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	up	1.74	5.81e-03	Microarray data
GSE99298	mock_infected_0h	hRSV_NS1_L132A_L133A_infected_96h	up	5.44	3.48e-02	RNA-Seq data
GSE99298	mock_infected_0h	hRSV_NS1_Y125A_infected_96h	up	5.93	9.47e-10	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.58	1.73e-26	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.99	1.58e-30	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	1.82	2.34e-27	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-1.63	2.68e-02	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-1.53	3.78e-16	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-1.62	2.61e-12	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-1.90	1.59e-30	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Ensembl ID:	ENSG00000197122
Gene description:	SRC proto-oncogene, non-receptor tyrosine kinase
Chromosome:	20
Position	37344685-37406050
Protein class:	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Plasma membrane, Cytosol