P12814 (ACTN1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: ACTN1_HUMAN

UniProtID: P12814

Gene name(s): ACTN1

Protein name: Alpha-actinin-1

Gene ID: 87

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P12814-P27958PHISTO,biogrid,HPIDB18985028,14623081anti tag coimmunoprecipitation,two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.003). Show
Machine learning evidence: yes (score 0.459).
Combined Score: 0.965


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
4025ACTN1-PARVB complex20.50 (1/2)15159419CORUMView
5177Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)110.18 (2/11)11113628CORUMView
780CART complex480.12 (6/48)NAhu.MAPView
2122SLC9A3R1-ACTN4 complex60.17 (1/6)NAhu.MAPView
2322Affixin-actinin(alpha) complex40.25 (1/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE27702control_macrophagesFPV-infected_macrophagesdown-1.934.45e-02Microarray data
GSE32155HTB-3_unifectedHTB-174_infecteddown-2.371.10e-04Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_Anhui01_pCalu3_24hdown-1.788.68e-08Microarray data
GSE59226ControlVirus_infectiondown-1.632.50e-04Microarray data
GSE65574MCL001_mock_0hMCL001_RFP-MERS_0hdown-2.988.43e-03Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hdown-4.231.98e-04Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-6.053.55e-05Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-4.211.05e-03Microarray data
GSE65574MCL001_mock_7hMCL001_RFP-MERS_7hdown-3.325.73e-03Microarray data
GSE99298mock_infected_0hhRSV_NS1_Y125A_infected_96hup1.789.87e-05RNA-Seq data
GSE89008HTBE_H5N1_MOI0_mock_infected_12hHTBE_H5N1_MOI5_infected_12hdown-2.332.78e-27RNA-Seq data
GSE89008HTBE_H5N1_MOI0_mock_infected_18hHTBE_H5N1_MOI5_infected_18hdown-3.084.80e-75RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_12hMDM-418_H3N2_MOI2_12hdown-1.799.75e-04RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_18hMDM-418_H3N2_MOI2_18hdown-1.821.91e-23RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hdown-2.265.55e-39RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-2.733.29e-67RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-2.783.34e-96RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_12hMDM-513_H5N1_MOI2_12hdown-1.563.71e-27RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 60.2 Liver: 32.7 Gallbladder: 227.0 Duodenum: 50.6 Rectum: 122.5 Tonsil: 46.4 Stomach: 42.2 Salivary glanda: 46.5 Adipose tissue: 140.2 Lung: 97.6 Lymph node: 55.0 Pancreas: 9.5 Kidney: 26.4 Colon: 117.2 Appendix: 205.7 Smooth musle: 754.0 Breast: 87.4 Parathyroid gland: 14.7 Esophagus: 172.5 Heart muscle: 72.0 Spleen: 76.5 Skeletal muscle: 3.5 Bone marrow: 98.4 Skin: 23.4 Urinary bladder: 204.4 Cervix, uterine: 103.9 Endometrium: 327.8 Ovary: 42.0 Fallopian tube: 168.7 Seminal vesicle: 410.3 Prostate: 287.4 Epididymis: 73.6 Testis: 41.3 Placenta: 138.5 Thyroid gland: 38.0 Cerebral cortex: 68.4 Adrenal gland: 53.5
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000072110
Gene description:Actinin alpha 1
Chromosome:14
Position68874143-68979440
Protein class:Disease related genes, Plasma proteins, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Plasma membrane, Focal adhesion sites